Cardinals vs. 49ers Free Pick

NFL Week 12 Free Pick & Prediction: Cardinals vs. 49ers

The Arizona Cardinals routed the San Francisco 49ers already once this season. Will they do it again today at 4:05PM ET?

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According to oddsmakers at, the Cardinals are the big favorite on the road, as they are getting odds of -8.5 points against the 49ers. The over/under total for the contest has been set at 45 points.

The Cardinals are 8-2 on the year, 4-1 on the road and 6-4 against the spread while the 49ers are 3-7 overall, 3-2 at home and 4-6 against the spread. The home team has won three straight, but the Cardinals have covered the spread in those three games. Arizona picked up a 47-7 win over San Fran back on Sept. 27 and they are looking for a fifth straight win to increase its NFC West lead.

Arizona beat the Niners by 40 in their first meeting. The Niners have just not been competitive in most games. They scored just three points at home against Seattle and three against Green Bay, two teams comparable with Arizona. Expect Carson Palmer and company to take this game seriously because it's a division game and it's a rivalry. Chris Johnson and Andre Ellington can run the ball and setup play-action passes to Larry Fitzgerald and John Brown.


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