Bills vs. Saints Thanksgiving Prediction

Bills vs. Saints, 11/25/21 Thanksgiving Day NFL Betting Predictions & Odds

The third and final game of the NFL Thanksgiving Day triple-header is a non-conference matchup between the Bills and Saints at 8:20 p.m. ET. With how banged-up New Orleans is, will Buffalo cover as a 6-point road favorite or is there a better play on the board?

Game Snapshot

109 Buffalo Bills (-6) at 110 New Orleans Saints (+6); o/u 45

8:20 p.m. ET, Thursday, November 25, 2021

Superdome, New Orleans, LA


Buffalo Bills DFS Spin

New York Upstate's Ryan Talbot writes, "Don’t be surprised if Thursday becomes the Matt Breida game." Talbot notes coach Sean McDermott responded with a definitive, "Yes," when asked in a radio interview if Breida has earned more opportunities. Breida only played 32 percent of the snaps and touched the ball just six times against the Colts, but both of those totals were higher than his breakout the week before. With the Bills in desperate need of an effective running game, Breida at least has a shot to pull away from Zack Moss and Devin Singletary. Breida remains too risky to trust in most redraft leagues, but he could be a good DFS option on Thanksgiving.

New Orleans Saints DFS Spin

Alvin Kamara (knee) will not play in Week 12 against the Bills. Meanwhile, Mark Ingram is listed as questionable after logging a limited practice. Kamara was unable to practice throughout the short week leading up to the Saints' Thanksgiving matchup with the Bills. He'll get another week of rest before attempting to play in Week 13 versus the Cowboys. If Ingram plays, he'll be a high-end RB2, coming off 40 touches in two starts. Tony Jones is the next man up if Ingram is also sidelined.

NFL Week 12 Betting Prediction

The Bills are 0-5 against the spread in their last five games against the Saints and are 1-3-1 against the number in their last five games overall. Meanwhile, the Saints are 8-2 against the number in their last 10 games as a home dog, are 35-17 against the spread in their last 52 games as an underdog and are 4-1 at the betting window in their last five games coming off a loss.


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