Cardinals vs. Seahawks Prediction

Cardinals vs. Seahawks, 11/21/21 NFL Week 11 Betting Predictions & Odds

NFC West rivals meet in Seattle on Sunday afternoon when the Seahawks host the Cardinals at 4:25 p.m. ET. With Seattle laying 2.5 points as a home favorite and the total sitting at 46 points, what’s the best bet when it comes to this division rivalry?

Game Snapshot

471 Arizona Cardinals (+2.5) at Seattle Seahawks (-2.5); o/u 46

4:25 p.m. ET, Sunday, November 21, 2021

Lumen Field, Seattle, WA

TV: FOX

Arizona Cardinals DFS Spin

ESPN's Adam Schefter reports Kyler Murray (ankle, game-time decision) will likely miss his third consecutive start Sunday. Per Schefter, the Cardinals are "not expected to make any final decisions until pre-game warmups," but that "(signs point) to Colt McCoy starting his third straight game." Murray was more involved in practice this week after missing Weeks 9 and 10, but the Cardinals are heading on bye in Week 12. They have probably made the determination that unless Murray is actually close to 100 percent health tomorrow, they aren't going to risk it, even for a divisional showdown with Seattle. With the game kicking off at 4:25 PM ET, fantasy managers need back-up plans in place by the morning.

Seattle Seahawks DFS Spin

Russell Wilson completed 20-of-40 pass attempts for 161 yards and two interceptions in the Seahawks' Week 10 loss to the Packers, adding five rushes for 32 yards. Wilson's 43.7 passer rating was the fourth worst of his ten-year NFL career. He was woefully inaccurate throughout the game, and looked to have decreased arm strength on a few throws to the boundary. Seattle's offense was continually denied on critical third downs, and Wilson had no answer for the Green Bay pass rush. Nineteen hours of daily rehab over the past month wasn't enough to get Wilson to 100 percent before his return -- that much was clear. He's a risky QB1 option in Week 11 against the Cardinals.

NFL Week 11 Betting Prediction

The Cardinals are 5-1 against the spread in their last six games in Seattle and are 6-2-1 against the number in their last nine games versus the Seahawks overall. The road team is also 9-3-1 at the betting window in the last 13 meetings between these two teams while the underdog is 9-2-1 against the spread in the last 12 meetings between these rivals.

NFL WEEK 11 PREDICTION: ARIZONA CARDINALS +2.5

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