Cardinals vs. Colts Pick

NFL Predictions: Arizona Cardinals vs. Indianapolis Colts 9/17/17

Which team should get back on track in Week 2 when the Indianapolis Colts host the Arizona Cardinals this afternoon at 1PM ET?

According to oddsmakers at, Arizona is favored on the road in this one, as the Cardinals are getting odds of -7 points against the Colts. The over/under total for the contest has been listed at 44 points. Indianapolis has won four of the last five against Arizona, but the Cardinals are 3-1 against the spread in the last four meetings. Today’s game takes place from Lucas Oil Stadium in Indianapolis, Indiana and will air live on FOX.

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Indianapolis looked horrible in Week 1, taking a 46-9 loss to the Rams in Los Angeles as a 3.5-point underdog. The Colts amassed just 225 yards of offense in the loss, committing three turnovers and allowing four sacks. Andrew Luck remains out, and the Colts weren’t happy with with Scott Tolzien gave them on Sunday, so Jacoby Brissett gets the start today despite being with the team for just a few weeks. Brissett came in last week and was 2 of 3 passing for 51 yards. Frank Gore was the leading rusher in last week’s loss with 42 yards on 10 carries. Defensively, the Colts allowed Jared Goff to light them up for 306 yards and a touchdown. Cornerback Vontae Davis will remain out indefinitely with an injury, so the secondary could continue to struggle.

Arizona started the season with a sloppy 35-23 loss at Detroit last week despite being a 2.5-point favorite on the road. Arizona had four turnovers in the loss. Carson Palmer was just 27 of 48 passing for 268 yards with one touchdown and three interceptions. David Johnson rushed for just 23 yards before suffering a wrist injury that landed him on the short-term IR. Kerwynn Williams will have to fill in for the time being, but he had just 10 rushing yards on five carries last week. Receiver John Brown was also injured in the loss and he is questionable to play today due to a quad injury. Defensively, the Cardinals were carved up by Matthew Stafford for 292 yards and four touchdowns, though the unit did manage an early interception for a touchdown.

Bet on Cardinals vs. Colts

I have to believe the Cardinals aren’t as bad as they looked last week. Palmer looked every bit his age and just couldn’t get the offense moving against Detroit. Facing arguably the league’s worst pass defense should help him get on track. I don’t see Brissett having a great first start against Arizona. While the Cardinals gave up a lot of yards, they are still a dangerous unit capable of picking up a lot of sacks and turnovers. The Cards are 14-4 against the spread in their last 18 games after allowing over 250 passing yards the week before. I like Arizona to hammer this poor Indy team on the road.


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