UCLA vs Indiana Prediction: Will Bruins cover another big spread?

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UCLA enters this matchup as a heavy underdog against No. 3 Indiana. Despite a strong recent performance, the Bruins face a formidable challenge in Memorial Stadium. Here’s a comprehensive breakdown to guide your betting decisions.

Game Details

  • Date: Saturday, October 25, 2025

  • Kickoff: 12:00 p.m. ET (11:00 a.m. CT)

  • Location: Memorial Stadium — Bloomington, IN

  • TV: FOX

  • Weather: Clear skies with temperatures around 53°F

UCLA vs Indiana Betting Odds

  • Consensus Spread: Indiana −24.5 to −25.5

  • Total (O/U): 54.5

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Injury Report — Key Updates

UCLA

  • N. Davillier (DL): Probable (undisclosed)

  • A. Sanders (DL): Questionable (undisclosed)

  • J. Johnson (CB): Questionable (undisclosed)

Indiana

  • B. Bonds (CB): Out (undisclosed; season-ending)

  • L. Beebe Jr. (RB): Out (leg; season-ending)

  • T. Morris (WR): Out (knee; season-ending)

Note: UCLA’s defensive line depth is a concern, while Indiana’s offensive and defensive units remain largely intact.

Key Storylines

  • UCLA’s Resurgence: After an 0–4 start, UCLA has won three consecutive Big Ten games, showcasing a potent rushing attack averaging 233 yards per game over the last three contests.

  • Indiana’s Dominance: Currently ranked No. 3 nationally, Indiana boasts an undefeated record and a high-powered offense led by quarterback Fernando Mendoza, who has thrown for 1,755 yards and 21 touchdowns.

  • Defensive Concerns: UCLA’s defensive line faces challenges with key injuries, potentially impacting their ability to contain Indiana’s explosive offense.

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Prediction — The Confident Call

Bet: Indiana −24.5

Rationale:

  • Offensive Firepower: Indiana’s offense is averaging over 30 points per game, with Mendoza’s leadership at the helm.

  • Defensive Depth: Despite the loss of a key cornerback, Indiana’s defense remains formidable.

  • UCLA’s Challenges: UCLA’s defensive line injuries may struggle against Indiana’s offensive line, leading to potential breakdowns.

Projected Score: Indiana 42, UCLA 17

UCLA vs Indiana Prediction

Bet: Indiana −24.5

Rationale:

  • Offensive Firepower: Indiana’s offense is averaging over 30 points per game, with Mendoza’s leadership at the helm.

  • Defensive Depth: Despite the loss of a key cornerback, Indiana’s defense remains formidable.

  • UCLA’s Challenges: UCLA’s defensive line injuries may struggle against Indiana’s offensive line, leading to potential breakdowns.

Projected Score: Indiana 42, UCLA 17

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