Last Updated on November 15, 2025 10:53 am by Michael Cash
LAS VEGAS, NV — The Week 12 Saturday slate brings one of the most wide-ranging odds boards of the season, stacked with heavyweight matchups, double-digit favorites, and several live underdog opportunities across the Top-25. With playoff positioning tightening and market movement accelerating, this week’s card produced three standout edges for our College Football Week 12 Best Bets picks along with two longshot plays that carry legitimate upset potential.
Want to see how our College Football Week 12 Best Bets stack up against public tickets? Check out our College Football Public Betting Chart before locking in your plays.
Week 12 College Football Best Bets
⭐ Best Bet #1 — Georgia Tech (#16) −16.5 vs Boston College
Georgia Tech continues to profile as one of the more undervalued Top-25 teams. Their offense has become more efficient on early downs, and the defense forces long fields with consistency. Boston College struggles to sustain drives and can fall behind quickly if Tech lands the first punch. Market structure supports a two-score separation, and the gap in trench play should widen across four quarters.
Georgia Tech −16.5 / Total 61 / ML −800
Boston College +16.5 / ML +525
⭐ Best Bet #2 — Miami Florida (#15) −15.5 vs NC State
Miami’s defense has tightened in November, and this matchup tilts significantly toward the Hurricanes’ front seven. NC State has struggled with pressure-heavy looks, and Miami has the personnel to exploit those tendencies. If Miami controls scripted plays and forces NC State into predictable passing situations, this number can get away from the Wolfpack quickly.
Miami −15.5 / Total 55 / ML −675
NC State +15.5 / ML +460
⭐ Best Bet #3 — Iowa (#21) +6.5 at USC (#17)
Iowa’s defensive profile makes them one of the most difficult road underdogs to pull away from, even in hostile environments. USC has been inconsistent on early downs and overly reliant on explosive plays, which Iowa is uniquely built to limit. The Hawkeyes’ physicality and field-position advantage give them a clear path to covering in a game that should stay within one score.
Iowa +6.5 / Total 48.5 / ML +200
USC −6.5 / ML −240
Week 12 Underdogs With Upset Potential
💥 Live Dog #1 — Pittsburgh (#22) +12.5 at Notre Dame (#9)
Pitt’s defense has the right structure to frustrate Notre Dame’s rhythm, and the Panthers have improved at limiting explosive plays. If they avoid turnovers and win red-zone efficiency, they can extend possessions, shorten the game, and keep the Irish uncomfortable deep into the second half.
Pitt +12.5 / Total 54.5 / ML +355
Notre Dame −12.5 / ML −490
💥 Live Dog #2 — Oklahoma (#11) +6 at Alabama (#4)
Oklahoma’s offensive variance makes them a dangerous underdog, especially in matchups where explosives can swing outcomes quickly. Alabama is the deserving favorite, but the Sooners’ ability to stretch the field and generate chunk plays gives them real upside. If this becomes a pace-up script, Oklahoma’s chances spike dramatically.
Oklahoma +6 / Total 45.5 / ML +180
Alabama −6 / ML −220
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