Iowa State vs. Wisconsin, 3/20/22 March Madness Betting Predictions

Iowa State vs. Wisconsin Prediction

The Wisconsin Badgers needed a second half comeback to knock off a pesky Colgate team in the first round of the tournament while Iowa State had little trouble getting past LSU in its opening round game. Which side will cover when the two teams meet in the second round on Sunday night at 6:10 p.m. ET?

Game Snapshot

821 Iowa State Cyclones (+4.5) vs. 822 Wisconsin Badgers (-4.5); o/u 125.5

6:10 p.m. ET, Fiserv Forum, Milwaukee, WI

TV: TNT

March Madness Betting Prediction

The Cyclones are 5-1 against the spread in their last six neutral site games as an underdog, are 5-1 against the number in their last six neutral site games overall and have cashed in four of their last five games as an underdog either home, away or on a neutral floor. Iowa State is also 19-7 against the spread in its last 26 games on Sunday and has cashed in five of its last seven games when facing an opponent with a winning record.

On the other side, the Badgers are just 2-5 against the spread in their last seven NCAA Tournament games when listed as a favorite, which includes a failed cover as a 7.5-point favorite against Colgate in the first round on Friday night. Wisconsin is also 1-3-1 against the spread in its last five NCAA Tournament games overall, is 2-7 against the number in its last nine neutral site games as a favorite and is winless against the number in its last four games overall.

MARCH MADNESS BETTING PREDICTION: IOWA STATE CYCLONES +4.5