Wednesday CBB Best Bets Jan. 21: Can Cincinnati cover 7 of 9?

Wednesday features a full college basketball slate with several mid-major and high-major schools in action on the third Wednesday of January. Can Nebraska stay unbeaten and cover as home favorites against Washington? Will scrappy Cincinnati hang tough with Arizona in a conference clash on Wednesday? Read on for our Wednesday CBB Best Bets Jan. 21 article.

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CBB Best Bet: Washington +11.5 over Nebraska

I like the Huskies here. Washington heads into Lincoln tonight as double-digit underdogs, but their recent performance suggests they can keep this game within the 11.5-point margin. Washington has been particularly sharp in Big Ten play, posting a 5-2 ATS record in conference games this season. The Huskies have also shown a gritty ability to bounce back, going 6-1 ATS following a loss this year. Furthermore, as an underdog, they have been a profitable play with a 4-3 ATS record in that role in 2025-26. With Hannes Steinbach dominating the glass, Washington has the interior presence to disrupt Nebraska’s rhythm and keep this game within the number. Final score projection: NEBRASKA CORNHUSKERS 82, WASHINGTON HUSKIES 75.

CBB Best Bet: Cincinnati +13.5 over Arizona

I’m backing the Bearcats in this contest. Cincinnati heads into the McKale Center as significant underdogs, but their recent form suggests they can keep this matchup within the 13.5-point margin. Cincinnati has been on a tear for bettors lately, posting a 6-2 ATS record in their last eight games overall. Their discipline translates well to Big 12 play, where they have maintained a 3-2 ATS mark in conference games this season. Furthermore, the Bearcats are highly effective on tight turnarounds, going 5-4 ATS when playing on 2 or 3 days of rest this year. Expect Cincinnati’s top-tier defense to prevent an Arizona blowout. Final score projection: ARIZONA WILDCATS 84, CINCINNATI BEARCATS 73.