Last Updated on August 22, 2025 8:00 am by Michael Cash
Friday, August 22, 2025 brings a loaded MLB slate, offering bettors plenty of opportunities to find value across the day’s matchups. Our MLB best bets spotlight three strong plays with favorable odds, supported by pitching analysis, lineup trends, and recent form. We also highlight two long-shot underdogs worth considering for plus-money payouts. Whether you’re targeting moneylines or run lines, today’s breakdown gives you the sharpest insights to navigate the board with confidence.
Friday’s Best Bets
Best Bet #1: New York Yankees ML (–168) vs Boston Red Sox
The Yankees hold a clear edge at home with their lineup in peak form and bullpen advantage. Boston’s rotation has been inconsistent on the road, giving New York the stronger moneyline angle.
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Best Bet #2: Philadelphia Phillies ML (–162) vs Washington Nationals
Philadelphia’s starter carries a decisive edge against a Nationals lineup that struggles away from home. The Phillies’ balanced attack and reliable pen make this a strong moneyline play.
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Best Bet #3: Pittsburgh Pirates –1.5 (+115) vs Colorado Rockies
The Rockies continue to struggle outside of Coors Field, and Pittsburgh has the bats to extend margins. At plus money, the run line offers far better value than the heavy moneyline.
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Today’s Value Long Shots
Long Shot #1: Cleveland Guardians ML (+135) at Texas Rangers
Cleveland’s rotation depth and contact-driven offense give them a shot to steal this matchup. With plus money on the table, the Guardians are a live dog worth a look.
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Long Shot #2: Miami Marlins ML (+139) vs Toronto Blue Jays
Miami’s pitching staff has been better at home, and if their bats can generate early runs, they have a real shot at pulling the upset. The plus-money tag makes this a smart underdog sprinkle.
Bet this pick now at Bovada
Quick Trend & Market Notes
- Yankees have won 6 of their last 8 against AL East rivals at home.
- Phillies continue to dominate the Nationals, winning 7 of the last 10 matchups.
- Pirates’ run line has been profitable vs. NL West teams at PNC Park.
- Guardians’ recent road games have trended under, but ML value exists in close contests.
- Marlins are a profitable play as home underdogs when priced above +130.
Today’s Card – August 22, 2025
| Matchup | Market | Odds |
|---|---|---|
| Yankees vs Red Sox | ML | Yankees –168 |
| Phillies vs Nationals | ML | Phillies –162 |
| Pirates vs Rockies | Run Line | Pirates –1.5 (+115) |
| Guardians at Rangers | ML (Long Shot) | Guardians +135 |
| Marlins vs Blue Jays | ML (Long Shot) | Marlins +139 |