Last Updated on August 26, 2025 6:35 am by Anthony Rome
As summer edges into September, the Chicago Cubs (76–55) head to Oracle Park to open a pivotal three-game set against the San Francisco Giants (63–68). The Cubs arrive red-hot with a three-game winning streak—looking to parlay momentum into postseason positioning in the National League. Meanwhile, the Giants, long since out of division contention, still sniff the playoffs and aim to maintain pressure as underdogs playing with something to prove.
Pitching Matchup: Boyd vs. Verlander
On the mound for Chicago is Matthew Boyd (12–6, 2.61 ERA)—a steadiness incarnate, particularly notable given this will be his first road outing in San Francisco over an 11-year career. Justin Verlander (1–10, 4.64 ERA) takes the bump for San Francisco—veteran pedigree meets a rough 2025 campaign, though he covers the Cubs well historically.
Team Trends & Heat Checks
Chicago’s offense has carried them through recent games, and defensively, they’ve looked sharp—especially with Boyd commanding the mound. Sportsbooks favor the Cubs at –142 moneyline, with the over/under set neatly at 7.5 runs.
Meanwhile, San Francisco, playing spoiler, has leaned on power from Willy Adames (22 HRs) and Heliot Ramos, hoping to expose Verlander’s rough patch. Notably, Verlander’s record in road starts this season has been particularly shaky.
What’s at Stake
For the Cubs, every win inches them closer to securing a comfortable wild-card or even challenging for their division. The Giants, though far from playoff pace, can shift the narrative with an upset—especially at home.
Cubs vs. Giants Betting Odds
According to oddsmakers from online sportsbook Bovada.lv, the Cubs are -134 moneyline favorites to beat the Giants, who are +121 moneyline underdogs. The total, meanwhile, is sitting at 7.5 runs.
As of this writing, our MLB Public Betting Page shows that 62% of the bets are on the Cubs’ moneyline. That said, this page is updated frequently so make sure that you click on the link provided so that you’re getting the most updated information.
Cubs vs. Giants Prediction
Expect a tight, high-leverage contest. Boyd’s focused consistency and the Cubs’ offensive rhythm give Chicago a credible edge. However, Verlander’s experience shouldn’t be understated—if he finds enough command, the Giants could hang around.
Projected Final Score: Cubs 6–5 Giants (Over 7.5 runs)
You heard it here: tight, tense, and maybe just enough offense to tip this toward Chicago.