Last Updated on August 20, 2025 6:54 am by Anthony Rome
The NL Central spotlight shines bright as the Brewers vs Cubs prediction takes center stage for Wednesday, August 20, 2025, at Wrigley Field. Milwaukee sends top prospect Jacob Misiorowski to the mound, while Chicago counters with the steady veteran Colin Rea. With playoff positioning at stake, this rivalry matchup carries extra weight for bettors and fans alike.
Brewers vs Cubs Prediction: Pitching Matchup
Jacob Misiorowski, the Brewers’ 6’7” flame-thrower, has quickly climbed into Milwaukee’s rotation with his overpowering fastball and improving command. While his strikeout numbers are eye-catching, control remains the X-factor against a Cubs lineup that thrives on grinding out at-bats.
Colin Rea, meanwhile, represents the opposite end of the spectrum—a journeyman who leans on pitchability and sequencing rather than pure stuff. He’s been serviceable at the back end of Chicago’s rotation, but he’ll need to be sharp against a Milwaukee lineup capable of punishing mistakes.
Brewers vs Cubs Prediction: Team Form & Trends
Milwaukee has built its reputation on pitching depth and timely hitting, with Christian Yelich’s resurgence continuing to anchor the lineup. Meanwhile, the Cubs are hanging tough in the Wild Card chase, relying on Nico Hoerner, Dansby Swanson, and Seiya Suzuki to keep their offense moving.
Recent meetings between these two clubs have been tight, with one-run games becoming the norm. Expect intensity on both sides, especially with the Wrigley faithful fueling Chicago’s energy.
Brewers vs Cubs Prediction: Odds & Betting Insight
This matchup is close to a pick’em, with slight variance depending on the book. According to oddsmakers from online sportsbook Bovada.lv, the Cubs enter as narrow favorites thanks to home-field advantage, though the Brewers’ upside behind Misiorowski gives Milwaukee backers plenty of value.
For a deeper look at how the public is betting this NL Central showdown, check out our MLB Public Betting Chart page for updates on all public betting figures.
Final Brewers vs Cubs Prediction
Ultimately, this game comes down to whether Misiorowski’s electric stuff outweighs his inexperience. If he limits walks, the Brewers hold the pitching edge. But Wrigley Field often tilts in Chicago’s favor, and the Cubs’ knack for working counts could force a short outing.
Prediction: Brewers win, 5–3, behind a strong Misiorowski debut at Wrigley, silencing the Cubs’ bats and giving Milwaukee a crucial road victory.