Cardinals vs. Padres Thursday Pick

St. Louis Cardinals vs. San Diego Padres, 5/10/2018 Prediction & Odds

The St. Louis Cardinals dropped back-to-back home games against the Twins after sweeping the Chicago Cubs last weekend. Will the Redbirds rebound when they open a new series in San Diego tonight against the Padres?

Game Snapshot & Odds

911 St. Louis Cardinals at 912 San Diego Padres; 7.5 runs

Thursday, May 10, 2018

10:10 p.m. ET, Petco Park


Compare odds and from multiple different online sportsbooks and shop for the best lines at our new Baseball Odds & Betting Page.

Public Betting Trends

Oddsmakers from online sportsbooks currently list the Cardinals as a -135 favorite. As of this writing, 75% of the betting tickets wagered at online sportsbooks are on the Cardinals to beat the Padres on the money line. This information is subject to change, however, so be sure to check out our MLB Public Betting Page for updated figures on this game.

Cardinals' Mikolas pitches seven scoreless innings in win

Miles Mikolas blanked the Cubs for seven innings on Friday to improve to 4-0 this year. Some teams have to be kicking themselves for not bettering the Cardinals' two-year, $15.5 million offer to Mikolas after all of the success he experienced in Japan. He has a 2.70 ERA at the moment, and the stuff is there to make him a pretty good bet going forward.

Padres' Lyles to start Thursday vs. Cardinals

Jordan Lyles will start on Thursday against the Cardinals. He's taking the rotation spot of Bryan Mitchell, who has been demoted to the bullpen. Lyles has been solid in relief this season with a 3.66 ERA and 16/7 K/BB ratio over 19 2/3 innings, but the 27-year-old holds a career 5.32 ERA over 107 starts at the major league level. His leash will be short.

MLB Betting Trends

St. Louis

The Cardinals are 5-1 in their last six games in San Diego and have won 10 of their last 13 games versus the Padres overall.

San Diego

The under is 4-1-1 in the last six meetings between these two teams.


The Padres have been bad in series meetings with the Cardinals and are just 1-6 in their last seven games coming off a win. They're also 3-12 in their last 15 home games versus a right-handed starter and are 8-21 in their last 29 games versus a right-handed starter, too. On the side, the Cardinals are winless at 0-4 in their last four road games but are 5-2 in their last seven games overall and Mikolas has been great for them.


The Pick: St. Louis Cardinals -135


MLB Headlines

MLB Predictions & Picks

Thumbnail Red Sox vs. Astros MLB Prediction Following the Astros’ come-from-behind victory last night against the Red Sox, Houston will look to take a 2-0 series lead on Saturday afternoon when these two teams...
Thumbnail Red Sox vs. Astros ALCS Game 1 Pick Game 1 of the ALCS is set for 8:07 p.m. ET on Friday when the Astros host the Red Sox on FOX. With Chris Sale set to oppose Framber Valdez, which side has the edge...
Thumbnail Dodgers vs. Giants Game 5 Prediction It all comes down to Thursday night in San Francisco when the Giants host their bitter rivals the Dodgers for Game 5 of the NLDS at 9:07 p.m. ET. Which team will...
Thumbnail Giants vs. Dodgers Game 4 Prediction The Giants are on the verge of eliminating the Dodgers and punching their ticket to the NLCS following their 1-0 win in Game 3 of the NLDS on Monday night. Is San...
Thumbnail Brewers vs. Braves Game 4 Prediction The Braves can eliminate the Brewers in Game 4 of the NLDS at 5:15 p.m. ET on Tuesday. With Charlie Morton set to face the Brewers for a second time in this...