SAN FRANCISCO, CA (The Spread) - The Cubs and Giants will open a new series in San Francisco tonight at 10:05PM ET.

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According to oddsmakers from online sports book GT Bets, the red-hot Cubs are -136 money line favorites over the Giants, who are +126 money line underdogs. With Jake Arrieta set to face Matt Cain in the pitching matchup, the total is sitting at 6.5 runs.

The under is 9-1-1 in the last 11 meetings between the Cubs and Giants in San Francisco, 5-1 in Cain's last six home starts versus the Cubs, and 9-3 in his last 12 starts overall versus Chicago.

The under is also 5-2-2 in the Giants' last eight games overall, 9-2-2 in their last 13 games as a home underdog and 8-2-1 in their last 11 home games. The under is 5-2-1 in Arrieta's last eight starts as a favorite.

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