SAN FRANCISCO (AP) - Running back Brandon Jacob's debut with the San Francisco 49ers will have to wait at least another week.
Jacobs is among those inactive for San Francisco against the Buffalo Bills on Sunday. The big, burly former New York Giants running back has not played since injuring his left knee in the preseason. He practiced this week without limitations and had declared himself healthy enough to play.
Rookies LaMichael James and A.J. Jenkins also were inactive for the 49ers.
The Bills got a boost with safety Jairus Byrd (hip) and wide receiver Ruvell Martin (ankle) on the active roster. Both were listed as questionable earlier in the week. Martin also plays on special teams.

Recent NFL Discussions

2017 NFL Draft Grades on Sun, Apr 2017 by Blade
Betting the 2017 NFL Draft on Tue, Apr 2017 by Blade
NFL Draft Preview on Tue, Apr 2017 by Blade
2017 Heisman Odds on Wed, Mar 2017 by Blade
College / NBA today on Sun, Mar 2017 by TtomBoBadly

Top NFL Public Bets

NFL Top Stories

Thumbnail NFL Draft Prop Odds The 2017 NFL Draft gets underway later tonight. Here is a look at some of the featured prop odds for tonight’s first round.
Thumbnail Alabama NFL Draft Odds The Alabama Crimson Tide could have a lot of players taken in the first round of the NFL Draft next week. How many...
Thumbnail Odds Theory & Fantasy: Perfect Combo In America alone over 110 million people settled down to watch February’s Super Bowl and were rewarded by a game which saw many twists and turns along the way. Of...
Thumbnail Romo moving to CBS After a lot of discussion about where Tony Romo will be next season, it appears that he will be behind a broadcast booth.

NFL Team Pages