BUFFALO (2-2) At SAN FRANCISCO (3-1)
Sunday, 4:25 p.m., CBS
OPENING LINE – 49ers by 10
RECORD VS. SPREAD – Buffalo 2-2; San Francisco 3-1
SERIES RECORD – Tied 5-5
AP PRO32 RANKING – Bills No. 20; 49ers No. 3
LAST MEETING – 49ers beat Bills 10-3 ,Nov. 30, 2008
LAST WEEK – Bills lost to Patriots 52-28; 49ers beat Jets 34-0
BILLS OFFENSE – OVERALL (11), RUSH (4), PASS (22)
BILLS DEFENSE – OVERALL (27), RUSH (28), PASS (23)
49ERS OFFENSE – OVERALL (19), RUSH (3), PASS (30)
49ERS DEFENSE – OVERALL (3), RUSH (6), PASS (5)
STREAKS, STATS AND NOTES – Teams have alternated wins in last six matchups. … Last time either team won consecutive games over other was when San Francisco won in 1983 and 1989. … RB Brandon Jacobs, out with left knee injury since preseason, could make season debut for 49ers. … Bills LT Cordy Glenn and RG Kraig Urbik both hurt right ankles in 52-28 loss to New England and not expected to play. … Game marks first of three straight and five of six at home for San Francisco. .. Trip to Bay Area begins stretch of four of five on road for Buffalo. … Rather than returning home following game, Bills will travel to Arizona, where they’ll practice for week before facing Cardinals. … Bills WR Stevie Johnson born in San Francisco and attended high school in Fairfax, Calif., just over Golden Gate Bridge in Marin County. … 49ers S Donte Whitner drafted eighth overall by Buffalo and played for Bills from 2006-10. … 49ers have not allowed touchdown rushing in 11 straight home games, longest active streak in NFL. … In winning at Cleveland two weeks ago, Bills snapped eight-game road losing streak. … Bills QB Ryan Fitzpatrick leads NFL with 12 touchdown passes. He’s also tied for second-worst with seven interceptions. … 49ers QB Alex Smith tied for 14th with five touchdowns. He’s tied for second-best with one interception.
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