BUFFALO (2-2) At SAN FRANCISCO (3-1)
Sunday, 4:25 p.m., CBS
OPENING LINE - 49ers by 10
RECORD VS. SPREAD - Buffalo 2-2; San Francisco 3-1
SERIES RECORD - Tied 5-5
AP PRO32 RANKING - Bills No. 20; 49ers No. 3
LAST MEETING - 49ers beat Bills 10-3 ,Nov. 30, 2008
LAST WEEK - Bills lost to Patriots 52-28; 49ers beat Jets 34-0
BILLS OFFENSE - OVERALL (11), RUSH (4), PASS (22)
BILLS DEFENSE - OVERALL (27), RUSH (28), PASS (23)
49ERS OFFENSE - OVERALL (19), RUSH (3), PASS (30)
49ERS DEFENSE - OVERALL (3), RUSH (6), PASS (5)
STREAKS, STATS AND NOTES - Teams have alternated wins in last six matchups. ... Last time either team won consecutive games over other was when San Francisco won in 1983 and 1989. ... RB Brandon Jacobs, out with left knee injury since preseason, could make season debut for 49ers. ... Bills LT Cordy Glenn and RG Kraig Urbik both hurt right ankles in 52-28 loss to New England and not expected to play. ... Game marks first of three straight and five of six at home for San Francisco. .. Trip to Bay Area begins stretch of four of five on road for Buffalo. ... Rather than returning home following game, Bills will travel to Arizona, where they'll practice for week before facing Cardinals. ... Bills WR Stevie Johnson born in San Francisco and attended high school in Fairfax, Calif., just over Golden Gate Bridge in Marin County. ... 49ers S Donte Whitner drafted eighth overall by Buffalo and played for Bills from 2006-10. ... 49ers have not allowed touchdown rushing in 11 straight home games, longest active streak in NFL. ... In winning at Cleveland two weeks ago, Bills snapped eight-game road losing streak. ... Bills QB Ryan Fitzpatrick leads NFL with 12 touchdown passes. He's also tied for second-worst with seven interceptions. ... 49ers QB Alex Smith tied for 14th with five touchdowns. He's tied for second-best with one interception.
---
Online: http://pro32.ap.org/poll and http://twitter.com/AP-NFL

Recent NFL Discussions

2017 Heisman Odds on Wed, Mar 2017 by Blade
College / NBA today on Sun, Mar 2017 by TtomBoBadly
SNOW on Tue, Mar 2017 by Michael Cash
EARLY COLL PLAYS FOR WED. on Wed, Mar 2017 by Timmy1961

Top NFL Public Bets

NFL Top Stories

Thumbnail The Next Atlanta Falcons Despite suffering one of the greatest collapses in sports history at Super Bowl LI, the Atlanta Falcons still managed to overcome significant odds to reach the NFL’s...
Thumbnail Eddie Lacy 2017 Prop Odds After signing with the Seahawks earlier this month, how many touchdowns and rushing yards will Eddie Lacy earn in 2017?
Thumbnail DeSean Jackson Bucs Prop Odds How many touchdowns will DeSean Jackson post with his new team in 2017? Here's a look at the odds.
Thumbnail Brandin Cooks Patriots Prop Odds How many total receiving yards will new Patriot Brandin Cooks have in 2017?
Thumbnail Alshon Jeffery TD Prop Odds How many touchdown passes and receiving yards will Alshon Jeffery rack up in 2017? Oddsmakers have released projections for the newest Eagle.

NFL Team Pages