It had been 11 years since Nos. 1 and 2 lost on the same day before LSU and California pulled the trick last week.
In this unpredictable college football season, would it be all that surprising to see the top two teams in the AP poll and the BCS standings go down in the same weekend again?
Top-ranked Ohio State and No. 2 South Florida both face unranked opponents. But 10 teams with top-10 rankings have already lost to unranked opponents, so what's a couple more?
The Buckeyes' (7-0, 3-0 Big Ten) first game this season as No. 1 will be at home against Michigan State and former Ohio State defensive coordinator Mark Dantonio, who in his first season as head coach has the Spartans (5-2, 1-2) well positioned for their first winning season since 2003.
Dantonio has the Spartans getting after the quarterback, they're second in the nation in sacks with 29, and running the ball well (243 yards per game).
Ohio State's rise from No. 11 to start the season includes only one victory over a team that's been ranked at any point this season.
South Florida, the feel-good story out of the Big East, faces last year's feel-good story out of the Big East. The Bulls (6-0, 1-0) visit Rutgers on Thursday night.
The Scarlet Knights (4-2, 1-1), who started the season 16th in the rankings, broke a two-game losing streak with a win over Syracuse last week. Another conference loss would put Rutgers' league title hopes in peril.
The picks:
Thursday
No. 2 South Florida (minus 2 1/2) at Rutgers
Scarlet Knights stopped late 2-point conversion to beat Bulls last season ... USF 24-23.
Saturday's Games
Michigan State (plus 17) at No. 1 Ohio State
Buckeyes have won 10 of 12 against Spartans ... OHIO STATE 28-10.
No. 4 Oklahoma (minus 29) at Iowa State
Cyclones have worst offense in Big 12 ... OKLAHOMA 48-14.
No. 18 Auburn (plus 11) at No. 5 LSU
Auburn won last season's Tiger Fight 7-3 ... LSU 21-13.
Vanderbilt (plus 13) at No. 6 South Carolina
Gamecocks coach Steve Spurrier has never lost to Vandy ... SOUTH CAROLINA 34-17.
No. 7 Oregon (minus 11) at Washington
The 100th meeting between Ducks and Huskies ... OREGON 35-21.
No. 14 Florida (minus 7) at No. 8 Kentucky
Gators have won 20 straight against Wildcats ... FLORIDA 34-28.
Mississippi State (plus 23 1/2) at No. 9 West Virginia
Mountaineers won first meeting 42-14 last season in Starkville ... WEST VIRGINIA 41-17.
No. 10 California (no line) at UCLA
Status of Cal QB Nate Longshore (ankle) questionable ... UCLA 28-24.
No. 13 Southern California (minus 18) at Notre Dame
USC has won five straight vs. ND, though last trip to South Bend needed Bush Push to win ... USC 34-14.
No. 15 Kansas (minus 4) at Colorado
KU QB Todd Reesing debuted vs. Buffs last season with three TDs ... KANSAS 29-17.
No. 22 Texas Tech (plus 3 1/2) at No. 15 Missouri
Red Raiders are No. 1 passing team in nation; Tigers are fifth ... MISSOURI 54-43.
No. 19 Texas (minus 24 1/2) at Baylor
Longhorns have scored 125 points in last two seasons against Bears ... TEXAS 50-17.
No. 20 Tennessee (plus 1) at Alabama
Volunteers have won 10 of 12 in rivalry ... ALABAMA 31-28.
No. 23 Cincinnati (plus 9 1/2) at Pittsburgh
How bad has it gotten for Panthers? Their coach is injured ... CINCINNATI 33-21.
No. 24 Michigan (minus 2 1/2) at Illinois
Wolverines are 38-4-2 against Illini since 1959 ... ILLINOIS 28-24.
No. 25 Kansas State (plus 3) at Oklahoma State
Cowboys have run for more than 200 yards in six straight games ... KANSAS STATE 34-30.
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Last week's record: 15-6 (straight); 13-7-1 (vs. points)
Season: 123-25 (straight); 67-62-2 (vs. points)
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