CLEVELAND (AP) -Derek Anderson threw five touchdown passes, Jamal Lewis rushed for 215 yards and the Cleveland Browns, so desperate after losing their home opener they traded their starting quarterback, outlasted the Cincinnati Bengals and Carson Palmer 51-45 on Sunday.
Anderson had a breakout game against the Browns (1-1), going 20-of-33 for 328 yards and the five TDs, which tied a team record shared by Frank Ryan, Bill Nelsen, Brian Sipe and Kelly Holcomb.
A week ago, Anderson was backing up Charlie Frye before being brought in during the first half. Two days later, the Browns dealt Frye to Seattle.
Palmer went 33-of-50 for 401 yards and tossed a career-high six TDs, but his final chance to rally the Bengals (1-1) ended when he was intercepted with 21 seconds left by Leigh Bodden, who made a diving grab near Cleveland's sideline.
It was just the third time in NFL history that two QBs threw five TD passes in the same game. Oakland's Tom Flores (6) and Houston's George Blanda (5) both did it on Dec. 22, 1963, and Billy Kilmer of New Orleans (6) and Charley Johnson of St. Louis (6) also did on Nov, 5, 1969.
Johnson had 11 catches for 209 yards and two TDs, and jumped headfirst after the second score into the Dawg Pound, where he was baptized in a shower of beer by Cleveland's rowdiest fans.
Packers 35, Giants 13
EAST RUTHERFORD, N.J. (AP) - Brett Favre picked a near-perfect way to become the winningest quarterback in NFL history.
Favre completed his first 14 passes of the second half and threw three touchdown passes to rally the Green Bay Packers over Eli Manning and the New York Giants. The victory was the 149th of Favre's 17-year career, giving him one more win than Hall of Famer John Elway.
It also gave the Packers their first 2-0 start since they won their first three in 2001.
The loss was the second straight for the undisciplined and error-prone Giants, something that hasn't happened at the start of a season since 1996.
Favre was 29-of-38 for 286 yards, including 18-of-21 for 147 yards in the second half. He threw a go-ahead 2-yard touchdown pass to Bubba Franks on the Packers' opening series of the second half. Rookie DeShawn Wynn added touchdown runs of 6 and 38 yards.
Manning, whose playing status was uncertain all week because of a sprained shoulder, was 16-of-29 for 211 yards, including a 26-yard touchdown pass to Plaxico Burress.
Texans 34, Panthers 21
CHARLOTTE, N.C. (AP) - With Matt Schaub throwing for 227 yards and two touchdowns and backed up by an effective running game, the Houston Texans forced three turnovers and recovered from a sluggish start to go 2-0 for the first time in franchise history.
Houston went 24-56 in its first five years with David Carr, who was released in the offseason when the Texans traded for Schaub. Carr, now the Panthers backup, could only watch as Andre Johnson caught seven passes for 120 yards and two scores, Ahman Green rushed for 71 yards and a TD and the Texans rallied from a 14-0 deficit. They handed the Panthers (1-1) their fourth consecutive loss in their home opener.
With Carolina fans booing by midway through the third quarter, Houston was enjoying its team-record fourth straight win dating to last season and looked ready to finally contend for a playoff berth in its sixth year.
The Panthers' Steve Smith, who caught eight passes for 153 yards and three TDs, had little help. Jake Delhomme threw for 307 yards, but had an interception. DeShaun Foster lost a fumble.
Colts 22, Titans 20
NASHVILLE, Tenn. (AP) - Peyton Manning threw for 312 yards and a touchdown, and the Indianapolis Colts held off Tennessee when their defense stopped Vince Young on a final-drive comeback.
Unlike last December, when Rob Bironas capped a similar comeback with a 60-yard field goal, the Colts collapsed around Young on fourth-and-4. That forced him to lob the ball away in the final seconds.
Manning, 28-of-42, kneeled down to run out the final seconds as champion Indianapolis (2-0) reminded Tennessee (1-1) which team remains atop the AFC South.
Adam Vinatieri had one of his worst days in years despite making field goals of 22, 39 and 20 yards. He had an extra point blocked and a field goal partially blocked that bounced off the crossbar before going over. He also missed a 36-yarder.
Young was 17-of-27 for 184 yards and a touchdown, but couldn't lead the Titans to 2-0 for the first time since 1999.
49ers 17, Rams 16
ST. LOUIS (AP) - Dante Hall fumbled while catching a punt and Marcus Hudson recovered for San Francisco, setting up the winning field goal by Joe Nedney.
The Rams' Jeff Wilkins missed a 56-yard field goal try with 59 seconds to play, the ball falling about a yard short of the goal post.
The 49ers (2-0) won despite struggling offensively most of the game. St. Louis (0-2) had 392 total yards to 186 for San Francisco. Alex Smith was 11-for-17 for 126 yards. Frank Gore scored two touchdowns and gained 81 yards on 20 carries.
Marc Bulger was 24-for-41 for 368 yards and one touchdown. Isaac Bruce caught eight passes for 145 yards. Rams running back Steven Jackson gained 60 yards on 21 carries.
The Rams were up 13-7 and on the verge of another score when Torry Holt caught a pass at the San Francisco 10 and was stripped from behind by Nate Clements. The ball skipped into the end zone, then out of bounds, giving San Francisco the ball at the 20.
The 49ers' drive appeared to stall with a fourth-and-1 at the St. Louis 43, but coach Mike Nolan went for it. Gore took a handoff up the middle and got the first down after he appeared stopped by linebacker Chris Draft. But Draft lost his grasp of the running back, who ran to the end zone to make it 14-13.
Buccaneers 31, Saints 14
TAMPA, Fla. (AP) - Joey Galloway caught four passes for 135 yards and two touchdowns, tormenting the Saints for the sixth straight game between the NFC South rivals and leading the Buccaneers to a victory.
The Saints (0-2) were embarrassed for the second consecutive week and have been outscored 72-24 after having one of the NFL's most explosive offenses and reaching the NFC championship game last season.
Jeff Garcia completed 10 of 16 passes for 243 yards and no interceptions for the Bucs (1-1).
Galloway has had some of his best games as a Buccaneer against New Orleans, scoring 10 touchdowns, nine receiving and one on a punt return, in six meetings.
Drew Brees was 26-of-44 for 260 yards with one touchdown for the Saints, but never got into a rhythm. Deuce McAllister had nine carries for 47 yards at the half, but only carried once for 2 yards the rest of the way. Reggie Bush finished with 27 yards on 10 rushes and 43 yards on six receptions.
Steelers 26, Bills 3
PITTSBURGH (AP) - Willie Parker ran for a touchdown and 126 yards, and Ben Roethlisberger threw for a score as the Pittsburgh Steelers controlled the clock and the tempo while pulling away from Buffalo.
It was the Bills' first game since tight end Kevin Everett badly injured his spinal cord.
Buffalo's J.P. Losman couldn't generate any offense as the Bills were outgained 421-223. The Steelers, whose first four scores came on field goals by Jeff Reed, finally took control with the game's only two touchdowns in the final quarter and a half.
Mike Tomlin won his home opener as Steelers' coach, just as Bill Cowher (1992) and Chuck Noll (1969) did before him. Tomlin also matched Cowher by winning his first two games. The Bills, with Everett believed to be watching from his hospital room, lost their fourth in a row counting their final two of last season.
Losman had only two completions for 5 yards until the Bills (0-2), down by two touchdowns-plus, began throwing on nearly every down. He finished 15 of 25 for 154 yards.
Jaguars 13, Falcons 7
JACKSONVILLE, Fla. (AP) - The Jaguars sacked Joey Harrington seven times and held the Atlanta Falcons under 100 yards rushing.
Atlanta's biggest problem came on special teams, where rookie Matt Prater missed two field goals. His second miss Sunday would have given the Falcons (0-2) a 10-3 advantage. Instead, David Garrard drove Jacksonville (1-1) on consecutive scoring drives to put the team ahead for good.
Garrard was 17-of-25 for 272 yards, including a 14-yard touchdown pass to Reggie Williams. The Jaguars added two more sacks on the ensuing possession, forcing a punt and taking advantage of good field possession to get in field-goal range.
Harrington finished 12-of-20 for 200 yards. Warrick Dunn had 50 yards rushing and the lone score. Jerious Norwood added 30 yards on the ground.

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