Cardinals vs. Seahawks Sunday Prediction

Cardinals vs. Seahawks, 12/22/19 NFL Week 16 Against the Spread Predictions

Following the 49ers’ win on Saturday night over the Rams, the Seahawks need to beat the Cardinals on Sunday to set up a huge NFC West showdown next week in Seattle. Will the Hawks cover as a 9-point home favorite today at 4:25 p.m. ET?

Game Snapshot

477 Arizona Cardinals (+9) at 478 Seattle Seahawks (-9); O/U 51

4:25 p.m. ET, Sunday, December 22, 2019

CenturyLink Field, Seattle, WA

Public Betting Trends

According to our NFL Football Public Betting Chart page, the Seahawks are receiving 55% of the betting tickets from online sportsbooks.

Arizona Cardinals Fantasy Spin

Cardinals WR Christian Kirk (ankle) is a game-time decision for the team's Week 16 matchup against the Seahawks. Kirk is set up well if active against the Seahawks' mediocre group of CBs outside of Shaquill Griffin (hamstring), who is banged up and shaping up as a game-time decision himself. Larry Fitzgerald would likely see all the targets he can handle if Kirk is ultimately ruled out. Damiere Byrd (34% snaps in Week 15) split reps with Andy Isabella (25%), Pharoh Cooper (20%) and Trent Sherfield (3%) in Week 15, as the Cardinals instead embraced two-TE formations with Kirk (89%), Fitzgerald (77%), Charles Clay (70%) and Maxx Williams (66%)

Seattle Seahawks Fantasy Spin

Bobby Wagner (ankle) wasn't listed on the Seahawks' final injury report. Wagner didn't practice this week, but he'll suit up in Week 16 against the Cardinals. His presence is bad news for Kenyan Drake, who continues to dominate usage. He's racked up at least 14 touches in every game since joining the Cardinals in Week 9. Week 16's road matchup against the Seahawks isn't ideal for the league's 18th-ranked scoring offense, but Drake's talent and workload has him firmly on the RB1 borderline.

NFL Betting Trends


The Cardinals are just 12-25-1 against the spread in their last 38 games after allowing more than 350 total yards in their previous contest.


The Seahawks are 28-12-3 against the spread in their last 43 games after accumulating more than 250 yards passing in their previous contest.


The Cardinals are 4-1-1 against the spread in their last six games versus the Seahawks and have covered four straight meetings with the ‘Hawks in Seattle. The road team is also 8-1-1 against the number in the last 10 meetings between these two teams while the underdog is 7-1-1 at the betting window in the last nine meetings. The Seahawks are just 2-5 against the spread in their last seven home games and have failed to cover in five of their last seven games as a home favorite. The Cardinals, meanwhile, are 5-1-1 against the spread in their last seven games when listed as a road underdog and are 5-1-1 ATS in their last seven road games overall.

NFL Week 16 Prediction: Arizona Cardinals +9

Recent NFL Discussions

NFL Predictions & Picks

Thumbnail Best NFL Players Not in the Hall of Fame Not so long ago, the NFL Hall of Fame was replenished with eight more names of the best football players of all time.
Thumbnail 49ers vs. Eagles Prediction & Odds The Eagles will be slight favorites when they host the 49ers in the NFC Championship Game on Sunday at 3:00 p.m. ET. Even with a rookie under center, is San...
Thumbnail NFC Championship Game Total Prediction The total for Sunday’s NFC Championship Game between the 49ers and Eagles opened at 45.5 but has been bet up to 46.5.
Thumbnail Bengals vs. Chiefs Prediction & Odds Patrick Mahomes will suit up for the Chiefs when they host the Bengals as 1.5-point home favorites in Sunday’s AFC Championship Game at 6:30 p.m. ET.
Thumbnail AFC Championship Game Total Prediction With Patrick Mahomes set to play the AFC Championship Game despite suffering a high ankle sprain in last week’s win over the Jaguars, many believe that the...

NFL Headlines