Panthers vs. Bills Week 15 Prediction

Panthers vs. Bills, 12/19/21 NFL Week 19 Betting Predictions

The Bills have lost three of their last four games but are double-digit home favorites on Sunday against the Panthers at 1:00 p.m. ET. While Buffalo should rebound with a straight up win, will the Bills also come through for bettors?

Game Snapshot

307 Carolina Panthers (+13) at 308 Buffalo Bills (-13); o/u 44

1:00 p.m. ET, Sunday, December 19, 2021

Highmark Stadium, Orchard Park, NY


Carolina Panthers DFS Spin

D.J. Moore (hamstring) is questionable for Week 15. Panthers head coach Matt Rhule said Thursday that Moore should be able to suit up this week against the Bills. He was in and out of the lineup in Week 14 as he struggled through the hamstring issue. Moore is a precarious low-end WR2 against a tough Buffalo secondary. Moore has a 27 percent target share over the past five weeks. He has a strong 40 percent air yards share over that stretch.

Buffalo Bills DFS Spin

Bills head coach Sean McDermott said Josh Allen (foot) "should be ready to go" for Week 15 against the Panthers. Allen got in a limited practice Thursday and McDermott said he should practice in full on Friday. That's good enough to pencil him in against Carolina after he gutted out the foot injury in last week's loss to the Bucs. Allen's upside might be limited by the foot injury and potential game script issues -- the Bills are 10.5-point favorites -- but Allen remains a must-start fantasy option in Week 15.

Bills vs. Panthers Betting Prediction

The underdog is 4-1 against the spread in the last five meetings between these two teams, as is the road team. The Panthers are 8-1 against the spread in their last nine games as a road dog, are 10-3 against the number in their last 13 road games and are 11-5 at the betting window in their last 16 games as an underdog. The Bills, meanwhile, are just 2-5-1 against the spread in their last eight games overall and are 1-4 at the betting window in their last five games after allowing more than 250 yards passing in their previous game.


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