NFL Week 10 Point Spreads

NFL Week 10 Point Spread Odds & Over/Under Totals

Week 10 in the NFL will kick off Thursday night when Rex Ryan visits his former team and will conclude with an undefeated team featured on Monday Night Football.

View NFL Week 10 Odds

Thursday Night Football

Ryan will be making his first trip back to East Rutherford as a member of the Buffalo Bills this Thursday night. According to oddsmakers from online sports book BetDSI, the Bills are a 3-point road underdog at the Jets while the total has opened at 43 points for this AFC East matchup.

Sunday Night Football

NFC West rivals will clash in a pivotal divisional matchup at 8:30PM ET on NBC when the Seahawks host the first-place Cardinals. Seattle opened as a 3-point home favorite for this matchup and that's where the number currently sits. The total, meanwhile, is listed at 45 points.

Monday Night Football

The undefeated Bengals will be a double-digit home favorite for the second straight week when they host the Texans at 8:30PM ET. Cincinnati covered as a 13-point home favorite last Thursday versus Cleveland and is currently a 10.5-point home favorite versus Houston for Monday Night Football. The total currently sits at 47 points.

Biggest Spread

The Packers are an 11.5-point home favorite over the Lions for the NFC North rivals' 1:00PM ET kickoff at Lambeau Field on Sunday. Green Bay opened as a 13-point home favorite but the number has already been bet down.

Smallest Spread

Of the point spreads listed (check our NFL odds page for updated spreads), the Saints-Redskins matchup in Washington has the smallest odds at the moment. The game opened as a pick'em but New Orleans is now a 1-point road favorite versus Washington, which failed to cover as a 14-point underdog last Sunday in Foxboro.

NFL Week 10 Point Spreads

109 Buffalo Bills +3 (43)

110 New York Jets -3

251 Detroit Lions +11.5 (47.5)

252 Green Bay Packers -11.5

253 Dallas Cowboys N/A

254 Tampa Bay Buccaneers N/A

255 Carolina Panthers -4 (42)

256 Tennessee Titans +4

257 Chicago Bears N/A

258 St. Louis Rams N/A

259 New Orleans Saints -1 (51)

260 Washington Redskins +1

261 Miami Dolphins N/A

262 Philadelphia Eagles N/A

263 Cleveland Browns N/A

264 Pittsburgh Steelers N/A

265 Jacksonville Jaguars +6.5 (48)

266 Baltimore Ravens -6.5

267 Minnesota Vikings N/A

268 Oakland Raiders N/A

269 Kansas City Chiefs N/A

270 Denver Broncos N/A

271 New England Patriots -7.5 (55)

272 New York Giants +7.5

273 Arizona Cardinals +3 (45)

274 Seattle Seahawks -3

275 Houston Texans +10.5 (47)

276 Cincinnati Bengals -10.5

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