Cardinals vs. 49ers Prediction

Cardinals vs. 49ers, 11/7/21 NFL Week 9 Betting Predictions

With questions surrounding the health status of Kyler Murray and DeAndre Hopkins, will the 49ers post a win and a cover against the visiting Cardinals on Sunday at 4:25 p.m. ET?

Game Snapshot

471 Arizona Cardinals (+4) at 472 San Francisco 49ers (-4); o/u 44.5

4:25 p.m. ET, Sunday, November 7, 2021

Levi’s Stadium, Santa Clara, CA


Arizona Cardinals DFS Spin

ESPN's Adam Schefter reports Kyler Murray (ankle) will "test his injury in pre-game warmups before Arizona makes a final decision on his status." Murray went down with the ankle injury at the end of his Week 8 loss to the Packers and did not practice in any capacity this week. Cardinals general manager Steve Keim has already noted that the team will consider the "big picture" when deciding if Murray will play this week. If Murray does go, expect a more run-heavy approach from the Cardinals as they attempt to protect their franchise passer. Murray, who has been running less this year before the injury, would rank as a low-end QB1 if he goes. Colt McCoy will draw the start if he sits.

San Francisco 49ers DFS Spin

ESPN's Adam Schefter reports Deebo Samuel (calf) is expected to play in Week 9 against the Cardinals. Samuel has been dealing with the calf issue for multiple weeks but Kyle Shanahan noted that the injury was worse leading into the team's Week 9 contest. He will need to make it through a final check in warmups but Samuel appears to be ready to go. Samuel is averaging 115.5 receiving yards per game, a mark that trails only Cooper Kupp. Despite the lingering calf issue, he remains a WR1 versus the Cardinals this week.

Cardinals vs. 49ers Betting Prediction

The road team is 7-3-1 against the spread in the last 11 meetings between these two teams while the underdog is 5-1-1 against the number in the last seven meetings. The Cardinals, meanwhile, are 6-1-1 at the betting window in their last eight games against the 49ers and are 4-0-1 against the spread in their last five games at Levi’s Stadium.


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