Cardinals vs. Browns Week 6 Prediction

Cardinals vs. Browns, 10/17/21 NFL Week 6 Betting Predictions

The Cardinals will put their unbeaten record on the line when they visit the Browns at 4:05 p.m. ET on Sunday. Arizona is catching over a field goal as a road underdog but is Cleveland the better bet to cash?

Game Snapshot

267 Arizona Cardinals (+3.5) at 268 Cleveland Browns (-3.5); o/u 48.5

4:05 p.m. ET, Sunday, October 17, 2021

FirstEnregy Stadium, Cleveland, OH

TV: FOX

Arizona Cardinals DFS Spin

Kyler Murray (shoulder) was limited in Thursday's practice for the second straight day. Murray got some attention from trainers in the fourth quarter versus the 49ers. Even despite the limited tag there's not been a lot made about Murray's status for Week 6, and we're expecting him to be a locked-in QB1 play yet again for a date against the Browns barring a bombshell dropping on Friday.

Cleveland Browns DFS Spin

Baker Mayfield completed 23-of-32 passes for 305 yards and two touchdowns in the Browns' 47-42, Week 5 loss to the Chargers. It was Mayfield's first multi-touchdown passing game of the season after he entered the day with two touchdowns through four games. This was easily his best game of the young year on the stat sheet. Mayfield's two touchdowns went to Rashard Higgins from seven yards out and then David Njoku on a 71-yarder. Mayfield won't be a recommended fantasy option in Week 6 against the Cardinals.

Cardinals vs. Browns Betting Prediction

The Cardinals are just 1-5 against the spread in their last six games when facing an opponent with a winning record, while the Browns have covered in five of their last seven games and are 8-2 at the betting window in their last 10 games after accumulating more than 150 yards rushing in their previous game. Cleveland has also cashed in five of its last six games coming off an ATS loss.

NFL WEEK 6 BETTING PREDICTION: CLEVELAND BROWNS -3.5

Recent NFL Discussions

Loading...

NFL Predictions & Picks

Thumbnail Patriots vs. Bills MNF Prediction First place is on the line in the AFC East on Monday night when the Bills host the Patriots at 8:15 p.m. ET. Will the Patriots continue their hot play and pull off the...
Thumbnail Broncos vs. Chiefs Prediction The Sunday Night Football matchup in Week 13 pits AFC West rivals against each other when the Broncos visit the Chiefs at Arrowhead Stadium. Will the Chiefs cover as a...
Thumbnail 49ers vs. Seahawks Prediction NFC West rivals will meet in Seattle on Sunday when the struggling Seahawks host the 49ers at 4:25 p.m. ET. Will Russell Wilson’s domination over the 49ers continue or...
Thumbnail Ravens vs. Steelers Prediction AFC North rivals clash in Pittsburgh on Sunday where the Steelers will host the Ravens at 4:25 p.m. ET. Will Big Ben and the Steelers come through again as an underdog or...
Thumbnail Bucs vs. Falcons Prediction NFC South rivals will meet in Atlanta on Sunday where the Falcons will host Tom Brady and the Bucs at 1:00 p.m. ET. Is 10.5 too big a number to lay with the defending...

NFL Headlines