Seahawks vs. 49ers Week 4 Prediction

Seahawks vs. 49ers, 10/3/21 NFL Week 4 Betting Predictions

NFC West rivals clash in Santa Clara on Sunday when the 49ers host the Seahawks at 4:05 p.m. ET. Which of these teams coming off a loss in Week 3 will rebound in Week 4?

Game Snapshot

271 Seattle Seahawks (+2.5) at 272 San Francisco 49ers (-2.5); o/u 52

4:05 p.m. ET, Sunday, October 3, 2021

NFL Week 4 Regular Season

Seattle Seahawks DFS Spin

ESPN's Adam Schefter reports Tyler Lockett (hip) is expected to play in Week 4 against the 49ers. Lockett practiced Friday after being downgraded to a DNP on Thursday. The veteran receiver has a history of posting middling fantasy numbers while playing through injuries but it's impossible to bench a receiver who has seen 20 targets from Russell Wilson through three games. Lockett is a risky fantasy option but his ceiling is worth chasing as a WR2.

San Francisco 49ers DFS Spin

George Kittle (calf) is questionable for Week 4 against the Seahawks. Coach Kyle Shanahan said the team will have a "good idea" by tomorrow whether Kittle can play, though they're at least encouraged at this time that he was able to participate in some capacity on Friday. Ross Dwelley, who averaged two targets per game across nine starts last year, would replace Kittle off the bench if the latter is ruled out.

Seahawks vs. 49ers Betting Prediction

The Seahawks are 13-5-1 against the spread in their last 19 games versus the 49ers, are 11-4 against the number in their last 15 games as an underdog and are 32-15-4 against the spread in their last 51 games following a loss. On the other side, the 49ers are 1-4 against the spread in their last five home games, are 10-26-1 against the number in their last 37 games as a favorite and are 5-21-1 at the betting window in their last 27 games as a home favorite.

NFL WEEK 4 BETTING PREDICTION: SEATTLE SEAHAWKS +2.5

Loading...

NFL Predictions & Picks

Thumbnail Bucs vs. Eagles TNF Prediction The Thursday Night Football matchup this week pits the defending Super Bowl champion Bucs against the 2-3 Eagles at 8:20 p.m. ET. Are 7 points too much to lay with the...
Thumbnail Colts vs. Ravens MNF Prediction The Colts and Ravens will wrap up Week 5 in the NFL season when the conference rivals meet at 8:15 p.m. ET in Baltimore. Will the Ravens cover as a 7-point home...
Thumbnail Bills vs. Chiefs SNF Prediction The NFL Sunday Night Football matchup this week features a rematch of last season’s AFC title game when the Chiefs host the Bills at 8:20 p.m. ET. With the Chiefs...
Thumbnail 49ers vs. Cardinals Week 5 Prediction NFC West rivals collide in Arizona on Sunday when Kyler Murray and the Cardinals host the 49ers and Trey Lance, who will make his NFL starting debut. Is red-hot...
Thumbnail Browns vs. Chargers Week 5 Prediction A pair of 3-1 teams will collide in L.A. on Sunday when the Chargers host the Browns at 4:05 p.m. ET. With Baker Mayfield banged up, will Justin Herbert and the...

NFL Headlines