Rams vs. Cardinals Prediction & Odds

Rams vs. Cardinals, 9/25/22 NFL Betting Predictions, Odds & Trends

NFC West rivals clash in Arizona on Sunday where the Cardinals will host the Rams at 4:25 p.m. ET. Given the Cards’ issues with the Rams in previous years, is L.A. the best play on the board when it comes to the spread?

Game Matchup & Betting Odds

485 Los Angeles Rams (-3.5) at 486 Arizona Cardinals (+3.5); o/u 48.5

4:25 p.m. ET, Sunday, September 25, 2022

State Farm Stadium, Tempe, AZ

Rams vs. Cardinals Public Betting Information

Our NFL Public Betting Information page indicates that 56% of public bettors are currently backing the Rams when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

Los Angeles Rams DFS Spin

Matthew Stafford completed 27-of-36 passes for 272 yards, three touchdowns, and two interceptions in the Rams' 31-27, Week 2 win over the Falcons. Stafford opened his day 10-of-10 for 100 yards and one score to Allen Robinson in the first quarter, and he was then able to find Cooper Kupp for a second touchdown in the second frame. But Stafford tosses his first pick on an end-zone shot to Tyler Higbee and was picked again trying to hit Kupp over the middle. Stafford and Kupp later hooked up for a second touchdown, but Stafford has failed to hit 300 yards in each of the first two games and sports a 4:5 TD:INT mark. Stafford is an extremely borderline QB1/2 who doesn't use his legs and gets a Week 3 date with the Cardinals.

Arizona Cardinals DFS Spin

Kyler Murray completed 31-of-49 passes for 277 yards, one touchdown and an interception in the Cardinals' 29-23, Week 2 overtime win over the Raiders, adding five carries for 28 yards and an additional score.  With Murray having all of 53 yards passing as the Cardinals trailed 20-0 at halftime, Arizona's contention in the rugged NFC West was looking all but over after last week's dismal loss to the Chiefs. Then Murray and the passing attack came alive despite a string of never-ending miscues, including a James Conner injury, dropped touchdowns, a delay-of-game on a two-point conversion, etc. Murray and his pass catchers made just enough plays to get the contest to overtime, none bigger than Murray's game-tying rushing scoring with zeros on the clock. It wasn't officially game-tying until Murray threaded an impossible seed to A.J. Green on the two-pointer even after Green almost single-handedly gave the contest away with drops. They almost won it with a huge strike to Marquise Brown in overtime but put the game on the defense's shoulders. It answered with a fumble six. Murray and his offense have major problems, including a continued lack of coherent pass-game design and no real boundary threat. They also still have Murray, whose singular play-making presence rivals that of anyone in the league. The Rams loom for Week 3.

Rams vs. Cardinals Betting Trends

Over is 6-1 in Rams last 7 games in September

Under is 5-2 in Rams last 7 vs. NFC West

Over is 4-1 in Cardinals last 5 home games

Rams vs. Cardinals Prediction:

The Rams are 9-1-1 against the spread in their last 11 games against the Cardinals and are a perfect 7-0 against the number in their last seven games in Arizona. The road team is also 11-4-1 against the spread in the last 16 meetings between these division rivals, while the favorite is 9-2-1 at the betting window in the previous 12 meetings. Despite winning outright last Sunday as an underdog, the Cardinals are still just 2-6 against the spread in their last eight games and are 1-4 against the number in their last five games following a win.


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