Bengals vs. Bills Week 3 Prediction

Bengals vs. Bills, 9/22/19 NFL Week 3 Predictions & Point Spreads

The Bills will look to improve to 3-0 on the young season when they play their home opener at 1:00 p.m. ET on Sunday versus the Bengals. Is six points too much to lay on the Bills, who could also improve to 3-0 ATS on the year?

Game Snapshot

467 Cincinnati Bengals (+6) at 468 Buffalo Bills (-6); O/U 44

1:00 p.m. ET, Sunday, September 22, 2019

New Era Field, Orchard Park, NY

Public Betting Trends

According to our NFL Football Public Betting Chart page, the Bills are receiving 59% of the betting tickets from online sportsbooks.

Cincinnati Bengals Fantasy Spin

Bengals LT Cordy Glenn (concussion) has been ruled out for the team's Week 3 matchup against the Bills. Backup LT Andre Smith (groin) and G Michael Jordan (knee) are questionable. The entire offense is set up poorly on the road against the Bills' ferocious defense. The Bengals rank 24th in adjusted sack rate and dead last in adjusted line yards per rush after two weeks (Football Outsiders).

Buffalo Bills Fantasy Spin

Devin Singletary (hamstring) has been ruled out for Week 3. This was expected after Singletary missed practice all week. Frank Gore will start, but T.J. Yeldon will have an expanded role with Singletary sidelined. Singletary's hamstring strain is of the lower-grade variety. There's hope he'll only end up sitting one game.

NFL Betting Trends


The Bengals are a perfect 5-0 against the spread in their last five road games and have covered in five of their last six overall.


The Bills have covered the spread in four straight games and are 5-2 ATS in their last seven conference matchups.


The Bills were a small underdog in Week 1 when they rallied in the fourth quarter to upend the Jets and at kickoff last Sunday against the Giants, had gone from a small dog to a small favorite. The Bengals, meanwhile, were trounced when they were a small favorite last week at home against the 49ers, but covered easily in a near-upset as a large underdog in Seattle in Week 1. This line looked right at Bills -4 but feels inflated at Buffalo -6. I’m going to roll the dice on the banged-up Bengals being slightly undervalued as a road dog.

NFL Week 3 Prediction: Cincinnati Bengals +6

Recent NFL Discussions

NFL Predictions & Picks

Thumbnail Best NFL Players Not in the Hall of Fame Not so long ago, the NFL Hall of Fame was replenished with eight more names of the best football players of all time.
Thumbnail 49ers vs. Eagles Prediction & Odds The Eagles will be slight favorites when they host the 49ers in the NFC Championship Game on Sunday at 3:00 p.m. ET. Even with a rookie under center, is San...
Thumbnail NFC Championship Game Total Prediction The total for Sunday’s NFC Championship Game between the 49ers and Eagles opened at 45.5 but has been bet up to 46.5.
Thumbnail Bengals vs. Chiefs Prediction & Odds Patrick Mahomes will suit up for the Chiefs when they host the Bengals as 1.5-point home favorites in Sunday’s AFC Championship Game at 6:30 p.m. ET.
Thumbnail AFC Championship Game Total Prediction With Patrick Mahomes set to play the AFC Championship Game despite suffering a high ankle sprain in last week’s win over the Jaguars, many believe that the...

NFL Headlines