Cardinals vs. Titans Prediction

Cardinals vs. Titans, 9/12/21 NFL Week 1 Betting Predictions

The Titans are only a 3-point home favorite versus the Cardinals on Sunday, but Arizona has had success covering the spread in previous meetings between these two teams. Who will cover at 1:00 p.m. ET when these teams meet in Week 1?

Game Snapshot

459 Arizona Cardinals (+3) at 460 Tennessee Titans (-3); o/u 53.5

1:00 p.m. ET, Sunday, September 12, 2021

NFL Week 1 Regular Season

Arizona Cardinals DFS Spin

Kyler Murray wants to run less in 2021. "Honestly, the way I see it is, my legs should be a luxury," Murray said. "And it kind of wasn't like that last year. It was me having to run for us in a sense. Once my shoulder was banged up and I wasn't trying to put myself out there and take those hits, we hit a lull. Honestly, I think it was a lesson for us. We can't be one-dimensional. We've got be better in all aspects of the game." Murray is correct that the Cardinals' offense went into a tailspin following his injury issues. It is more debatable if his legs can become a luxury. They might have to remain a necessity considering the way they unlocked Kliff Kingsbury's attack last season. Fantasy managers shouldn't worry about it too much. Especially as he remains in his early 20s, Murray essentially has no choice but to keep running as he hunts for big plays and tries to keep defenses off-balance.

Tennessee Titans DFS Spin

Ryan Tannehill was activated from the reserve/COVID-19 list. Tannehill was one of many Tennessee players and coaches who tested positive for the virus last week. RB Jeremy McNichols, who could be the team's No. 2 back while Darrynton Evans (knee) is on IR, was also taken off the COVID list on Saturday. After reluctantly getting the COVID-19 vaccine, Tannehill was removed from the COVID list after testing negative for the virus twice. ESPN's Adam Schefter said Tannehill is "on track" to start Week 1 against the Cardinals, whose inexperienced secondary makes Tannehill a top opening week fantasy option. The Titans-Cardinals game sports the week's second highest over-under (51.5).

Cardinals vs. Titans Betting Prediction

The Cardinals are 4-0 against the spread in their last four games versus the Titans and are 8-3-2 against the number in their last 13 games as a road underdog. On the other side, the Titans are 1-4 against the spread in their last five games in Week 1 and are 1-5 at the betting window in their last six games in September.

NFL WEEK 1 BETTING PREDICTION: ARIZONA CARDINALS +3

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