Colorado vs. USC Prediction & Odds

Colorado vs. USC, 11/11/22 CFB Betting Odds, Prediction & Trends

USC is a massive home favorite versus Colorado on Friday night at 9:30 p.m. ET in Southern Cal. Will the Trojans cover as 34.5-point home favorites in this Pac-12 matchup or is there a better play on the board?

Game Matchup & Betting Odds

121 Colorado Buffaloes (+34.5) at 122 USC Trojans (-34.5); o/u 66.5

9:30 p.m. ET, Friday, November 11, 2022

United Airlines Field at Los Angeles Memorial Coliseum

Colorado vs. USC Public Betting Information

As of this writing, our CFB Public Betting page shows that 56% of bets are on USC. That said, this page is updated frequently so make sure that you click on the link provided so that you’re getting the most updated information.

Colorado Buffaloes Game Notes

J.T. Shrout completed 17 of 34 passes for 247 yards, one touchdown and two interceptions during Saturday's 49-10 loss against Oregon. He also rushed three times for three yards. Shrout and the Buffaloes were outclassed by Oregon at almost every position. While Shrout has had flashes of excellence since taking over the QB duties, the offense has difficulty putting all the pieces together. Shrout has a chance to make a splash Friday night against USC, as the Trojans have struggled defensively all season long despite their elite offense.

USC Trojans Game Notes

USC coach Lincoln Riley said Thursday that Mario Williams (undisclosed) is a game-time decision to play in Friday's matchup with Colorado, Adam Grosbard of The Orange County Register reports. Like Jordan Addison (leg), Williams has also missed the last two games versus Arizona and California. However, while Addison is expected to play, the sophomore wideout's status is up in the air. If Williams doesn't play Friday, he should be ready to go for next Saturday's game versus UCLA.

Colorado vs. USC Betting Trends

Home team is 6-2-1 ATS in their last 9 meetings

Buffaloes are 0-4 ATS in their last 4 road games

Trojans are 3-9 ATS in their last 12 conference games

Colorado vs. USC Betting Prediction

The over is a perfect 4-0 in the Buffaloes’ last four road games, is 6-1 in their last seven road games versus a team with a winning home record and is 6-2 in their last eight games overall. On the other side, the over is 9-2 in the Trojans’ last 11 home games, is 4-1 in their last five games overall and is 4-1 in their last five conference matchups.

COLLEGE FOOTBALL WEEK 11 PREDICTION: COLORADO/USC OVER 66.5

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