Oregon vs. Colorado Prediction & Odds

Oregon vs. Colorado 11/5/22 Betting Prediction, Odds & Trends

Number eight Oregon travels to Boulder to face unranked Colorado at 3:30 PM ET on Saturday. Can the Buffaloes cover the spread as 31.5-point home underdogs?

Oregon is 7-1 on the year, with their best wins coming against BYU and UCLA. Their only loss came in Week 1 against Georgia. The Ducks are 6-2 ATS on the year. 

Colorado is 1-7 on the year with their only win coming against California. Their worst losses came against Air Force and Arizona. Colorado is 2-6 ATS on the year.

Game Matchup and Betting Odds

367 Oregon Ducks -31.5 at 368 Colorado Buffaloes +31.5; O/U 63 

3:30 PM ET Saturday, November 5th, 2022

Folsom Field, Boulder, CO

Oregon vs. Colorado Public Betting Information

The public favors the Ducks in this game. Our CFB Public Betting Page shows that 61% of public bets are on Oregon -31.5. Do note that those numbers are subject to change and could be different once game time rolls around. 

Oregon Game Notes

Oregon’s offense has been one of the most explosive in the nation this year. They are third in the country in yards per play (7.2), and tenth in the nation in points per play (0.538). Ducks quarterback Bo Nix has been the driving force behind Oregon’s offensive success this year. He’s thrown for 2,221 yards, 20 touchdowns, and 5 interceptions on the year. What’s more, Nix has also run for 441 yards and 11 touchdowns on the season. He’s been a true dual threat all year and will have to put up numbers if the Ducks want to cover this game.

Oregon’s best running back is Chicago product Bucky Irving. Irving has scored a touchdown in 4 of the Ducks’ last 5 games and is averaging 6.4 yards per carry on the season. He should see around 15-20 touches in this game because Colorado’s defense ranks 129th in opponent yards per rushing attempt.  

Colorado Game Notes               

The Buffaloes have had a difficult season thus far, but running back Deion Smith has been a bright spot. Smith had the best game of his career last weekend against Arizona State. In that contest, Deion Smith ran for 111 yards and a touchdown as the Buffaloes lost at home to the Sun Devils 42-34. Smith is averaging 5.1 yards per carry and 8.6 yards per catch this season so Colorado may want to increase his touches against Oregon on Saturday.

Colorado senior linebacker Josh Chandler-Semedo is one of the Buffaloes' best defensive players. He’s tied for third in the Pac-12 with 67 total tackles and he’s added 3 sacks, a pass defended, and a fumble recovery on the year. Chandler-Semedo must have a good game if Colorado wants to cover this large spread.

Oregon vs. Colorado Betting Trends

Oregon is 2-5 ATS in their last 7 road games.

Oregon is 8-19 ATS in their last 27 games after allowing more than 280 passing yards in their previous game.

Colorado is 6-1 ATS in their last 7 games in November. 

Colorado is 5-1 ATS in their last 6 games after allowing more than 280 passing yards in their previous game.

Oregon vs. Colorado Betting Prediction

Oregon’s offense is otherworldly. They’ve put up at least 40 points in each of their last 7 games. Colorado’s defense is one of the worst in the country, it’s safe to assume that Oregon will score 40+ points again. The question then becomes, can Colorado score enough to cover the spread? If their recent 4-game stretch is any indication, the answer is yes. Colorado beat Cal 20-13 a few weeks ago, and only lost by 8 points to Arizona State last week. I think Oregon might be looking ahead to their matchup with Washington next week, and that allows Colorado to narrowly cover the considerable spread.  


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