Clemson vs. Louisville Prediction

Clemson Tigers vs. Louisville Cardinals, 10/19/19 Predictions & Odds

Is No. 3 Clemson giving up too many points on the road when the Tigers take on Louisville this afternoon at Noon ET?

Game Snapshot & Odds

321 Clemson vs. 322 Louisville

Saturday, October 19, 2019

Noon ET – Cardinal Stadium


Compare odds and from multiple different online sportsbooks and shop for the best lines at our new NCAAF Odds & Betting Page.

Public Betting Trends

According to the latest oddsmakers, Clemson is favored on the road, as the Tigers are getting odds of -24 points against Louisville. The over/under total for the contest is listed at 61.5 points. The public betting currently has 63 percent going on Clemson as a road favorite. This information is subject to change, however, so be sure to check out our NCAAF Public Betting Page for updated figures on the game.

Cardinals pick up big win

The Louisville Cardinals are coming off a 62-59 win at Wake Forest last weekend in a shootout. The Cardinals are 4-2 on the season, 2-1 in the ACC, 4-2 against the spread and 3-3 with the over/under total.

Louisville has a pretty good offense this season, averaging 37.3 points and 490.5 yards per game. Defensively, the Cardinals are giving up 31.5 points and 439.3 yards per contest. Louisville has QB issues as Jawon Pass and Micale Cunningham are both dealing with injuries that have them questionable to play today. Cunning ham started against Wake, but had to leave with a head injury. He has thrown for 820 yards and seven touchdowns while rushing for 226 yards and three scores. Javian Hawkins has rushed for 622 yards and three touchdowns to lead the ground attack while Tutu Atwell has caught 32 passes for 509 yards and six scores.

Clemson hitting its stride

Clemson is coming off a 45-14 win over Florida State at home last weekend to stay unbeaten. The Tigers are 6-0 on the season, 3-0 in the ACC, 4-2 against the spread and 4-2 with the under.

The Tigers continue have a dominant defense, allowing just 12.3 points and 254.8 yards per game this year. Offensively, Clemson is putting up 39.2 points and 497 yards per game this season. Isaiah Simmons is leading the Clemson defense with 51 tackles and four sacks. Trevor Lawrence has thrown for 1,301 yards and 11 touchdowns with six interceptions. Travis Etienne is the leading rusher with 589 yards and five touchdowns. Tee Higgins is the team’s leading receiver with 24 catches for 549 yards and three touchdowns.

College Football Betting Trends


The Cardinals are just 5-14 ATS in their last 19 games at home and 7-20 ATS in their last 27 games in October.


The Tigers are 7-1 against the spread in their last eight road games and 9-2 ATS in their last 11 conference games.


Clemson has won five straight meetings with Louisville and covered the spread in the last three encounters. The Cardinals have been unable to slow down the Clemson offense and that should be the case again today. The Tigers are starting to hit their groove on offense and the defense is already stacked. The Cardinals have been able to do some good things on offense this year, but they are beat up at QB and are running into the best defense they have seen all season. I like Clemson to be able to cover either way, with their defense or offense leading the way.

College Football Week 8 Prediction: Clemson -24

Related: Clemson vs. Louisville Total Prediction

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