Cardinals vs. Pirates Prediction & Odds

Cardinals vs. Pirates, 10/5/22 MLB Betting Odds, Prediction & Trends

National League Central rivals the Cardinals and Pirates will wrap up their regular season at PNC Park at 4:05 p.m. ET. Will the Bucs pull off the small upset before heading into the offseason?

Game Matchup & Betting Odds

951 St. Louis Cardinals (-120) at 952 Pittsburgh Pirates (+100); o/u 7.5

4:05 p.m. ET, Wednesday, October 5, 2022

PNC Park, Pittsburgh, PA

Cardinals vs. Pirates Public Betting Information

As of this writing, our MLB Public Betting page shows that 65% of bets are on the Cardinals’ moneyline. That said, this page is updated frequently so make sure that you click on the link provided so that you’re getting the most updated information.

St. Louis Cardinals DFS SPIN

Cardinals manager Oli Marmol told reporters late Tuesday that Ryan Helsley (finger) "should be fine." Helsley was removed from an eighth-inning relief appearance Tuesday night in Pittsburgh after tweaking his right middle finger when he stumbled to the ground while fielding a comebacker. "Just on the way down after catching the line drive, he kind of jammed it," said Marmol. "But not anything where medical is super concerned about it. Not worth trying to pitch through it." The flamethrowing closer wrapped up the regular season with a dominant 1.25 ERA, 0.74 WHIP, and 94 strikeouts in 64 2/3 innings of work. He will presumably be available for Game 1 of the best-of-three Wild Card Series on Friday.

Pittsburgh Pirates DFS SPIN

Ke'Bryan Hayes told reporters that he's dealt with back discomfort for all of the 2022 season. Hayes said that it's from a hip issue that occurred during a workout early in the season. The 25-year-old has struggled throughout the season as seen in a slash of 245/.316/.347, and he's only hit 7 homers. Those struggles can at least partially be attributed to the issues with his back, although it didn't keep him from stealing 20 bases. There's certainly upside in Hayes' profile, but there's a lot of risk that comes with the reward potential.

Cardinals vs. Pirates MLB Betting Trends

Cardinals are 38-18 in the last 56 meetings in Pittsburgh

Over is 7-3 in the last 10 meetings

Cardinals are 41-17 in the last 58 meetings

Cardinals vs. Pirates MLB BETTING PREDICTION

The Cardinals have dropped four of their last five road games, are 0-4 in their last four games after scoring five runs or more in their previous game and are 0-4 in their last four games after their opponent scores five runs or more in their previous contest. On the other side, the Pirates are 4-1 in their last five home games and are 4-0 in their last four games after allowing five runs or more in their previous contest.


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