Orioles vs. Red Sox Prediction & Odds

Orioles vs. Red Sox, 9/27/22 Betting Odds, Prediction & Trends

The Orioles won a slugfest with the Red Sox last night at Fenway Park but still find themselves listed as underdogs for Tuesday night’s matchup at 7:10 p.m. ET.

Will the O’s pull off another upset or is there a better option on the board for bettors?

Game Matchup & Betting Odds

971 Baltimore Orioles (+108) at 972 Boston Red Sox (-126); o/u 9

7:10 p.m. ET, Tuesday, September 27, 2022

Fenway Park, Boston, MA

Orioles vs. Red Sox Public Betting Information

As of this writing, our MLB Public Betting page shows that 56% of bets are on the Red Sox’ moneyline. That said, this page is updated frequently so make sure that you click on the link provided so that you’re getting the most updated information.

Baltimore Orioles DFS SPIN

Cedric Mullins tripled and homered Monday in a victory over the Red Sox. Mullins drove in three runs, and he scored twice. The homer was the 16th of the season -- a leadoff blast off an ineffective Connor Seabold -- while the speedy outfielder has procured four triples. Mullins hasn't been nearly as good in 2022 -- mainly because of his issues with left-handed pitching -- but still has provided some fantasy relevance with his power/speed combination.

Boston Red Sox DFS SPIN

Rob Refsnyder homered while going 3-for-4 with three RBI Monday in a loss to the Orioles. Refsnyder swatted a three-run homer in the seventh inning that brought the Red Sox to within five at 13-8. He also singled twice. The Red Sox have been a massive disappointment in 2022, but Refsnyder has been a (relative) bright spot with a slash of .315/.387/.514 with six homers in 146 at-bats.

Orioles vs. Red Sox MLB Betting Trends

Orioles are 4-9 in the last 13 meetings in Boston

Under is 3-1-1 in the last 5 meetings in Boston

Under is 4-1 in the last 5 meetings


The Orioles are 6-1 in their last seven road games versus an opponent with a losing record, are 5-1 in their last six games versus a right-handed starter and are 6-2 in their last eight road games overall. They’re also 24-11 in their last 35 games versus a team with a losing record, while the Red Sox are winless in their last six games overall. Boston has also dropped six straight games against a right-handed starter, is 0-4 in its last four home games when facing a team with a winning record and is 0-4 in its last four games when playing the second game of a series.


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