Cardinals vs. Cubs Prediction

St. Louis Cardinals vs. Chicago Cubs, 9/21/19 Prediction & Odds

The St. Louis Cardinals hold a three-game lead in the NL Central standings with eight games left to play and will look to move one step closer to winning the division today when they host a Chicago Cubs team on a four-game losing streak. Can Chicago snap its skid with a win this afternoon?

Game Snapshot

951 St. Louis Cardinals at 952 Chicago Cubs

Saturday, September 21, 2019

Wrigley Field at 2:20PM ET

TV: MLB Network

Compare odds from multiple different online sportsbooks and shop for the best lines at our MLB Odds & Betting Page.


Public Betting Information

According to oddsmakers, .the Cubs are a -128 favorite to win on the moneyline. The Cardinals are a +118 underdog, while the total has not yet been set due to Wrigley Field Wind factors. As of Saturday morning, 54 percent of public bets are siding with host Chicago. Check out our MLB Public Betting Page for the latest info.

Molina two-run single propels Cards

A two-run single by Yadier Molina in the top of the sixth inning propelled St. Louis to a 2-1 victory Friday afternoon at Chicago. Molina ended the contest 3-for-4 with two RBIs. Tommy Edman had the only other hit for the Cardinals as he finished 1-for-4 with a double. Paul Goldschmidt was 0-for-3 with two walks and a run scored. Ryan Helsley picked up the win in relief as he gave up one hit with one strikeout and no walks in one scoreless frame. Dakota Hudson will start today for St.Louis as he enters with a 16-7 record, 3.35 ERA and 1.39 WHIP plus 124 over 166 2/3 innings of work.

Cubs drop fourth straight

Chicago dropped to five games back in the NL Central and two games back in the NL Wild Card race with eight games to play as it fell 2-1 at home Friday afternoon against rival St. Louis. Kyle Schwarber helped pace the Cubs offense as he finished 2-for-4 with a double and a run scored. Nicholas Castellanos finished 2-for-3 with a double plus a walk. Jason Heyward also ended the contest 2-for-3 with a walk. David Phelps took the loss in relief as he walked the only two batters he faced and gave up two earned runs. Jose Quintana gets the start today as he comes in with a 13-8 record, 4.37 ERA and 1.34 WHIP plus 144 strikeouts over 162 2/3 innings pitched.

MLB Betting Trends

St. Louis

The Cardinals are 7-2 in the last nine Hudson Saturday starts. St. Louis is 5-2 in its last seven road games. 


The Cubs are 11-3 in the last 14 Quintana starts. St. Louis is 4-1 in the last five meetings.


The Cardinals have silenced the Cubs and their fans the first two games of the series, taking what was a dominant home team much of the season and turning them into not only an afterthought in the NL Central race but also a third-place team overall that is fighting for its playoff lives. While the Cubs basically need a win here to feel good about its Wild Card chances, St. Louis would like nothing more than to add more disappointment to its rivals in front of the Cubs' home fans. Hudson has had a competent season and with the Cardinals playing the better baseball overall right now, it isn't farfetched that this is the series where Chicago's playoff chances went into longshot territory.




MLB Headlines

MLB Predictions & Picks

Thumbnail Red Sox vs. Astros ALCS Game 1 Pick Game 1 of the ALCS is set for 8:07 p.m. ET on Friday when the Astros host the Red Sox on FOX. With Chris Sale set to oppose Framber Valdez, which side has the edge...
Thumbnail Dodgers vs. Giants Game 5 Prediction It all comes down to Thursday night in San Francisco when the Giants host their bitter rivals the Dodgers for Game 5 of the NLDS at 9:07 p.m. ET. Which team will...
Thumbnail Giants vs. Dodgers Game 4 Prediction The Giants are on the verge of eliminating the Dodgers and punching their ticket to the NLCS following their 1-0 win in Game 3 of the NLDS on Monday night. Is San...
Thumbnail Brewers vs. Braves Game 4 Prediction The Braves can eliminate the Brewers in Game 4 of the NLDS at 5:15 p.m. ET on Tuesday. With Charlie Morton set to face the Brewers for a second time in this...
Thumbnail Astros vs. White Sox Game 4 Prediction The White Sox staved off elimination by breaking out the bats last night in their rout of the Astros in Game 3. Will Chicago now even its series with Houston...