Cubs vs. Cardinals MLB Prediction

Cubs vs. Cardinals, 7/21/21 MLB Betting Predictions & DFS Notes

After choking in epic fashion last night, the Cardinals will look to rebound when they host the Cubs at 8:15 p.m. ET on Wednesday night. With Cardinal-killer Kyle Hendricks on the hill for Chicago, will the Cubs knock off their NL Central foe again tonight?

Game Snapshot

959 Chicago Cubs (+109) at 960 St. Louis Cardinals (-118); o/u 8

8:15 p.m. ET, Wednesday, July 21, 2021

Busch Stadium, St. Louis, MO

St. Louis Cardinals DFS SPIN

Alex Reyes blew his first save of the season Tuesday, getting charged with three runs while retiring only one batter as the Cardinals let a late six-run lead slip away against the Cubs. Reyes should have had the night off with St. Louis going into the ninth with a 6-1 advantage. However, he was summoned when the Cubs loaded the bases on a wild pitch on strike three, an infield single and a walk. Reyes walked in a run, bounced back with a strikeout and then walked in another run to bring the go-ahead run to the plate. Javy Baez singled in two to cut the deficit to one, and Ian Happ then provided the knockout blow with a two-run double. This inning certainly wasn't all Reyes' fault, but his poor control was bound to catch up to him at some point. He's walked 37 over 43 2/3 innings while also throwing a league-high nine wild pitches.

Chicago Cubs DFS Spin

Ian Happ doubled in the tying and go-ahead runs in the top of the ninth inning Tuesday as the Cubs completed a stunning comeback against the Cardinals. Happ didn't start the game but entered after Kris Bryant (hamstring) exited with an injury. He came up with the big hit against closer Alex Reyes, pulled one fair down the first base line to score Anthony Rizzo and Javy Baez. Happ hasn't been playing a ton lately, but he should see regular at-bats once the Cubs trade Bryant.

Cubs vs. Cardinals Betting Prediction

The Cubs are 6-2 in their last eight meetings versus the Cardinals, including last night’s come-from-behind victory in the top of the ninth. They rallied for six runs in the final frame to stun the Cardinals, who held a 6-1 lead heading into the ninth. The Cubs are also 6-2 in their last eight road games versus an opponent with a losing record, while the Cardinals are just 3-13 in their last 16 games versus divisional foes. They’re also 3-10 in their last 13 games after scoring five runs or more in their previous game.

MLB BETTING PREDICTION: CHICAGO CUBS +111

MLB Headlines

MLB Predictions & Picks

Thumbnail Pirates vs. Giants Prediction The Giants have owned the Pirates in previous meetings, including on Memorial Day where they hammered Pittsburgh, 14-4. Will the Giants’ domination of the Bucs continue on...
Thumbnail Yankees vs. Mariners Prediction The Yankees’ ownership of the Mainers continued on Monday night and with Nestor Cortes Jr. set to oppose Logan Gilbert in Tuesday night’s matchup, will the Bronx...
Thumbnail Twins vs. Astros Prediction The Twins took down the Astros in Game 1 of their series in Houston on Memorial Day. With Houston now an underdog for Game 2 at 8:10 p.m. ET, will the Astros even the...
Thumbnail Rays vs. Cubs Prediction One day after completely shutting the first-place Rays down, will the Cubs pull off another upset when the two teams continue their series at 8:05 p.m. ET on Tuesday from...
Thumbnail Royals vs. Cardinals Prediction After nearly no-hitting the Cardinals on Memorial Day, will the Royals pull off another upset at Busch Stadium on Tuesday night when these two...