Cubs vs. White Sox Prediction

Cubs vs. White Sox, 5/28/22 MLB Betting Odds & Predictions

Cross-city rivals will meet in the Windy City on Saturday night where the White Sox will host the Cubs at 7:15 p.m. ET. As Johnny Cueto makes another start for the host, will the White Sox cash as home favorites tonight?

Game Snapshot

931 Chicago Cubs (+120) at 932 Chicago White Sox (-141); o/u 8.5

7:15 p.m. ET, Saturday, May 28, 2022

Guaranteed Rate Field, Chicago, IL

Chicago Cubs DFS SPIN

Cubs manager David Ross told reporters on Thursday he was optimistic Seiya Suzuki won't have to be placed on the injured list with his left finger sprain. Suzuki suffered the injury in the third inning of Thursday's blowout loss to the Reds. The 27-year-old outfielder should get a day or two off as he recovers, but it appears he's avoided a serious injury and could be back in the lineup over the weekend -- assuming there are no setbacks, of course.

Chicago White Sox DFS Spin

Andrew Vaughn went 2-for-5 with five RBI on Thursday in the White Sox' lopsided defeat at the hands of the Red Sox. Vaughn did all of his damage in the early stages of the contest, walloping a three-run double against Red Sox' starter Michael Wacha in the third inning before also taking him deep for a two-run shot in the fifth inning. The 24-year-old outfielder has been excellent this season, hitting .292/.349/.500 with 11 runs scored, five homers and 19 RBI across 106 plate appearances.

Cubs vs. White Sox MLB BETTING PREDICTION

The Cubs are just 1-7 in their last eight games versus the White Sox, are 1-4 in their last five interleague games as an underdog and are winless in their last six interleague games when facing a right-handed starter. On the other side, the White Sox are 5-0 in their last five interleague home games, are 13-3 in their last 16 interleague games overall and are 10-4 in their last 14 games as a favorite.

MLB BETTING PREDICTION: CHICAGO WHITE SOX -141

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