White Sox vs. Astros Prediction

Chicago White Sox vs. Houston Astros 5/22/19, Prediction & Odds

The Houston Astros have had their way with the Chicago White Sox the first two games of the series and will go for another decisive win tonight with Gerrit Cole on the mound. Is Houston going to win on the runline again?

Game Snapshot

971 Chicago White Sox at 972 Houston Astros

Wednesday, May 22, 2019

Minute Maid Park at 8:10PM ET

TV: ATT SportsNet-SW

Compare odds from multiple different online sportsbooks and shop for the best lines at our MLB Odds & Betting Page.


Public Betting Information

According to oddsmakers, the Astros are a -325 favorite to win on the moneyline. The White Sox are a +295 underdog, while the total is set at 8.5 runs. As of Wednesday morning, 84 percent of public bets are pouring in on host Houston. Check out our MLB Public Betting Page for the latest information.

White Sox muster only one hit

Chicago had only one hit Tuesday night in a 5-1 defeat at Houston to drop to 21-26 on the season and 10-13 on the road. The lone hit came in the top of the seventh inning on a solo home run by Jose Abreu. He went 1-for-4 to lead the offense. Yonder Alonso and Yolmer Sanchez were both 0-for-2 with a walk. Dylan Covey suffered the loss as he surrendered four earned runs on four hits with one strikeout and four walks over four innings. Ivan Nova will start tonight for the White Sox as he enters with a 2-4 record, 7.42 ERA and 1.80 WHIP with 32 strikeouts over 47 1/3 innings.

Verlander carries no-hitter into seventh

Justin Verlander did not allow a hit until the seventh inning Tuesday night in a 5-1 home victory over Chicago. He gave up one earned run on one hit with a season-best 12 strikeouts and one walk over eight innings to pick up the win. Yuli Gurriel went 2-for-4 with a solo home run to help pace the offense. Michael Brantley was 1-for-4 with a double and two RBIs. Carlos Correa finished 1-for-3 with a walk and an RBI. Cole starts tonight for the Astros as he comes in with a 4-4 record, 3.56 ERA and 1.04 WHIP with 93 strikeouts over 60 2/3 innings.

MLB Betting Trends


The White Sox are 1-4 in their last five games overall. Chicago is 2-6 in the last eight Nova starts on grass.


The Astros are 14-3 in the last 17 home starts by Cole. Houston is 6-0 in the last six home games versus the White Sox.


Cole should be able to shut down this White Sox offense and it isn't very likely at all that Nova will return the favor. Houston is tough to beat at Minute Maid Park and even with George Springer out of the lineup, there are plenty of powerful bats to make up for his absence. Don't overthink this one and take the Astros on the runline once again.




MLB Headlines

MLB Predictions & Picks

Thumbnail Astros vs. Red Sox Game 4 Prediction The Boston Red Sox have taken a 2-1 series lead in their best-of-seven matchup with the Houston Astros after routing the visitors on Monday night. Will tonight’s game...
Thumbnail Braves vs. Dodgers Game 3 Prediction The Braves are up 2-0 on the Dodgers in the NLCS but will they take a commanding 3-0 series lead when the two teams play Game 3 on...
Thumbnail Astros vs. Red Sox Game 3 Prediction With the series now tied at one game apiece and shifting to historic Fenway Park, what’s the best play for Game 3 of the ALCS when the Red Sox host the Astros on...
Thumbnail Dodgers vs. Braves NLCS Game 2 Pick Austin Riley staked the Braves to a 1-0 series lead in their NLCS matchup with the Dodgers but will Los Angeles rebound in Game 2? First pitch is set for 7:38...
Thumbnail Dodgers vs. Braves Prediction Game 1 of the NLCS between the Dodgers and Braves will take place on Saturday night at 8:08 p.m. ET. Will the Dodgers earn a 1-0 series lead or are the Braves the...