White Sox vs. Red Sox Prediction

White Sox vs. Red Sox, 5/6/22 MLB Betting Odds & Predictions

The White Sox and Red Sox open a new series in Boston on Friday night when the two teams meet at 7:10 p.m. ET. With Vince Velasquez set to oppose Nathan Eovaldi in the pitching matchup, what’s the best bet for the series opener?

Game Snapshot

919 Chicago White Sox (+155) at 920 Boston Red Sox (-175); o/u 8.5

7:10 p.m. ET, Friday, May 6, 2022

Fenway Park, Boston, MA

Chicago White Sox DFS SPIN

White Sox placed OF Andrew Vaughn on the 10-day injured list, retroactive to May 2, with a bruised right hand. Vaughn suffered the injury last week when he got hit by a pitch and wasn't making enough progress on the side. The hope is that he will be ready to rock when he first becomes eligible for activation on May 12, which is next Thursday. The 24-year-old leaves behind a sparkling .283/.367/.566 batting line with four home runs and 12 RBI through 16 games played. Danny Mendick is up in a corresponding move.

Boston Red Sox DFS Spin

Trevor Story struck out all four times he was up Thursday against the Angels. Shohei Ohtani was incredible today, so Story's bad game was understandable. Still, he's having a brutal season to date, having hit just .210/.293/.296 in 92 plate appearances. He's struck out 29 times, and he still hasn't hit a home run. He should eventually get it together and make a contribution, but he'll likely rate as a 2022 fantasy disappointment based on where he was drafted.


The under is 9-4 in the last 13 meetings between these two teams in Boston, is 4-1-2 in the White Sox’ last seven games overall and is 7-3-1 in Chicago’s last 11 games as a road underdog. On the other side, the under is 10-4-1 in the Red Sox’ last 15 games overall, is 4-1 in their last five home games and is 5-1 in their last six games when facing a right-handed starter.



MLB Headlines

MLB Predictions & Picks

Thumbnail Red Sox vs. White Sox Prediction The Red Sox have won eight of their last 10 games but they’ve struggled to beat the White Sox, who are favored on Tuesday night at 8:10 p.m. ET. Is Boston worth a...
Thumbnail White Sox vs. Yankees Prediction The Sunday Night Baseball matchup will pit the White Sox against the Yankees in the Bronx after tempers flared on Saturday. Will the Yankees continue their...
Thumbnail White Sox vs. Yankees Prediction Following a rainout on Friday night in the Bronx, the White Sox and Yankees will attempt to play the series opener on Saturday afternoon at 1:05 p.m. ET. Will the...
Thumbnail Padres vs. Giants Prediction National League West rivals clash again on Saturday when the Padres and Giants continue their series from San Francisco at 4:05 p.m. ET. With Joe Musgrove set to oppose...
Thumbnail White Sox vs. Yankees Prediction The White Sox and Yankees open a new series in the Bronx on Friday night at 7:05 p.m. ET. Chicago has struggled in previous meetings against New York, but are the...