CHARLOTTE, N.C. (AP) — Carolina Panthers running back DeAngelo Williams is doubtful for Sunday's game against the New York Giants after missing his third straight practice with a sprained left ankle.

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Reserve running back Tyrell Sutton is also doubtful after sitting out Friday with a calf injury.

Williams was injured in the first quarter of last Sunday's win over Minnesota and didn't return. Jonathan Stewart replaced him and rushed for 109 yards and a touchdown.

Stewart is questionable with a sore left Achilles' tendon, but practiced Friday.

Quarterback Matt Moore (shoulder) and cornerback Richard Marshall (ankle) are also questionable. Both practiced Friday in a workout that took place on the Bank of America Stadium concourse because of heavy

Oddsmakers from online sports book Sports Interaction have made the Giants 7-point favorites over the Panthers in Week 16.

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Posted: 12/25/09 11:35PM ET

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