Detroit Lions quarterback Matthew Stafford has been held out of practice for the third time in four days, leaving his availability in question for Sunday's game at Green Bay.

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The No. 1 overall draft choice suffered a knee injury in Detroit's Oct. 4 loss at Chicago and sat out last weekend's game against Pittsburgh. Daunte Culpepper had 282 yards passing with a touchdown and an interception in the Lions' 28-20 loss.
Stafford did not practice Monday and Tuesday, took part in individual drills Wednesday and sat out again Thursday.
Coach Jim Schwartz said Thursday that he would let the Lions' injury report ``handle where we are with the quarterback.''

Oddsmakers from online sports book Sports Interaction have made the Lions 13.5-point underdogs at Green Bay in Week 4 against the Packers.

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Posted: 10/15/09 8:30PM ET