San Francisco 49ers running back Frank Gore is expected to miss three weeks because of a right ankle strain.

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The 49ers said Monday night that the strain was revealed during an MRI.
Gore injured the ankle on his only carry during Sunday's 27-24 loss to the Minnesota Vikings. He left the game after a four-yard gain and did not return.
Gore was taken to the locker room on a cart but X-rays revealed no broken bones.
The team says it is not related to the ankle sprain he sustained during his 207-yard rushing performance against the Seattle Seahawks on Sept. 20.
The 49ers also said tackle Joe Staley is day to day with a bruised right thigh and safety Reggie Smith has a strained right groin that will be re-evaluated in two weeks.

Thanks to their 2-1 start, the 49ers have gone from 60/1 to win Super Bowl XLIV to 30/1 according to oddsmakers from online sports book The Niners are 10-point favorites over the 0-3 Rams this Sunday and the over/under total for that matchup has been set at 37.5.

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Posted: 9/29/09 11:38AM ET