The No. 1 seeded Louisville Cardinals takes on surprising Siena this evening as the 2009 March Madness Tournament wraps up its second round. Let’s take a look at the odds, trends, injuries and hand out a College Basketball Free Pick for this matchup.

Bet Siena vs. Louisville

Tip off: 5:20PM ET

Odds: Oddsmakers from online sports book Sports Interaction have made Louisville 11.5-point favorite.

Over/Under Total: 142

Top Public Betting Trends:

Top Trends for this game.

LOUISVILLE is 21-13 ATS (+6.7 Units) in all games this season.

LOUISVILLE is 21-13 ATS (+6.7 Units) in all lined games this season.

LOUISVILLE is 47-32 ATS (+11.8 Units) as a favorite over the last 3 seasons.

LOUISVILLE is 19-10 ATS (+8.0 Units) in road games when playing against a team with a winning record over the last 2 seasons.

LOUISVILLE is 8-2 ATS (+5.8 Units) in road games when playing against a team with a winning record after 15 or more games this season.

LOUISVILLE is 21-37 ATS (-19.7 Units) in all neutral court games since 1997.

LOUISVILLE is 21-37 ATS (-19.7 Units) when playing on a neutral court since 1997.

Key Injuries:

SIENA

[F] 01/27/2009 - Cory Magee out for the season. (Concussion)

LOUISVILLE

[F] 03/22/2009 - Terrence Williams probable Sunday vs. Siena (Hand)

Free Pick: Our free pick for this game is Louisville –11.5.

Bet Siena vs. Louisville

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Posted: 3/22/09 10:23AM ET

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