Giants quarterback Eli Manning was knocked out of Sunday's game against the Washington Redskins after spraining his left ankle late in the first half of New York's 20-6 victory.
Manning started his 150th consecutive game, but was injured throwing an incomplete pass under pressure from defensive end Chris Baker. He was intercepted by Josh Wilson on the next play and limped off the field, heading directly to the locker room.
''It's serious, but you know it will heal,'' said Manning, who finished 10 of 24 for 152 yards with a touchdown and his career-high and NFL-leading 27th interception. ''I have an offseason to do that. I'm not worried about it being a lasting effect.''
Besides Manning, the Giants lost receivers Rueben Randle (knee), Hakeem Nicks (ankle) and offensive tackle Will Beatty (broken leg) in the regular-season finale. The Redskins saw cornerback Josh Wilson (calf) and defensive end Jarvis Jenkins (head) leave the game.
Seattle lost defensive tackle Brandon Mebane and tight end Luke Willson to injuries against St. Louis. Willson was taken off the field on a cart with 13 minutes remaining after suffering an injury to his lower left leg. He was placed in an air cast on the field and helped on to the cart after being tackled on a 4-yard reception. The play before the injury, Willson was open down the middle of the field for a possible touchdown, but the officials blew the play dead.
Mebane was announced as being out with a hip injury suffered in the second half. Mebane had six tackles Sunday and was extremely disruptive in the middle of the Seahawks' defense.
The Bengals had to reconfigure their offensive line again when center Kyle Cook suffered a foot injury and tackles Anthony Collins and Whitworth hurt ankles. X-rays on Cook were negative.
Indianapolis lost starting cornerback Vontae Davis with a groin injury, defensive lineman Aubrayo Franklin with a knee injury and linebacker Bjoern Werner with an ankle injury during the first half. Coach Chuck Pagano said all three would undergo further evaluations.
Miami wide receiver Brian Hartline left the Dolphins' 20-7 loss to the New York Jets in the first quarter with a left knee injury. He limped out of the game after a 25-yard reception that put him over the 1,000-yard mark for the second year in a row.
Jets cornerback Kyle Wilson left in the first half with a knee injury and didn't return.
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