CLEVELAND (AP) - Buffalo running backs C.J. Spiller and Fred Jackson will both play Thursday night against the Browns after being slowed by injuries.
Jackson, who leads the Bills with 256 rushing yards and two touchdowns, sprained his left knee last week in a win over Baltimore and will wear a brace. Spiller sprained his ankle in the third quarter against the Ravens and returned to practice Wednesday after missing the two previous days.
Last season against Cleveland, Spiller went out with a shoulder injury in the first half and third-stringer Tashard Choice ran for 91 yards in Buffalo's 24-14 win.
Also, the Bills will be without starting cornerback Stephon Williams and free safety Jairus Byrd.
Browns quarterback Brandon Weeden will back up starter Brian Hoyer. Weeden sprained his thumb in Week 2 and Hoyer is 2-0 in two starts. Jason Campbell is inactive.

Recent NFL Discussions

Handicapping 2017 Win Totals on Wed, May 2017 by Blade
2017 NFL Draft Grades on Sun, Apr 2017 by Blade
Betting the 2017 NFL Draft on Tue, Apr 2017 by Blade
NFL Draft Preview on Tue, Apr 2017 by Blade
2017 Heisman Odds on Wed, Mar 2017 by Blade

Top NFL Public Bets

NFL Top Stories

Thumbnail GM confident Falcons will sign Freeman Falcons general manager Thomas Dimitroff says he's confident that a deal with get worked out with running back Devonta Freeman.
Thumbnail Broncos' RB job open for competition The Broncos are set to have an open competition at running back for the 2017 season.
Thumbnail NFL Draft Prop Odds The 2017 NFL Draft gets underway later tonight. Here is a look at some of the featured prop odds for tonight’s first round.

NFL Team Pages