It's weeks such as these when the college football season can get turned upside down.
Only one game on the schedule matches ranked teams - South Carolina at Florida. Another game serves as a good reminder of how drastically the national championship race can change when it's least expected.
Southern California visits Stanford on Saturday, 13 months after the Cardinal ended the Trojans' 35-game home winning streak as a 41-point underdog.
USC was No. 2 in the country when it committed five turnovers and gave up the winning touchdown pass on fourth down with 49 seconds left to Stanford. In a 2007 season filled with memorable upsets, Stanford's stunner ranked among the most surprising.
An improved Stanford team, 5-5 under second-year coach Jim Harbaugh, is only a 23-point underdog as it goes for two straight against USC. The Trojans (8-1) can't afford another loss if they want to stay in the hunt for a national title.
Several other teams with much on the line face lightly regarded opposition Saturday.
the top-ranked Crimson Tide as a 20-point underdog.
Utah tries to stay unbeaten and keep its hopes of reaching the BCS alive at San Diego State. The Aztecs are a 28 1/2-point underdog.
Indiana, 34 1/2-point underdog, can do severe damage to Penn State's Rose Bowl hopes if the Hoosiers can pull off a Stanford-like upset.
And the one game matching ranked teams doesn't figure to be all that close either. Florida is a 21-point favorite over South Carolina and former Gators coach Steve Spurrier.
The picks:
Friday
No. 22 Cincinnati (minus 3 1/2) at Louisville
Bearcats are 1-9 in Battle for the Keg of Nails ... CINCINNATI 27-20.
Saturday
Mississippi State (plus 20) at No. 1 Alabama
Tide won't be Croomed by Bulldogs again ... ALABAMA 27-6.
No. 24 South Carolina (plus 21) at No. 3 Florida
Gamecocks have No. 1 D in SEC; Gators have No. 1 offense ... FLORIDA 37-13.
No. 4 Texas (minus 13 1/2) at Kansas
Jayhawks are 0-6 against Texas in Big 12 play ... TEXAS 48-28.
No. 6 Southern California (minus 23) at Stanford
Trojans have allowed 23 points in six-game winning streak ... USC 34-6.
Indiana (plus 34 1/2) at No. 7 Penn State
Hoosiers' porous D should give boost to Nittany Lions offense ... PENN STATE 49-20.
No. 8 Utah (minus 28 1/2) at San Diego State
BYU ... UTAH 44-13.
No. 9 Boise State (minus 34 1/2) at Idaho
Broncos averaged 59 points in last four games vs. Vandals ... BOISE STATE 59-14.
No. 10 Ohio State (minus 10) at Illinois
Illini beat Buckeyes in Columbus last year ... OHIO STATE 37-17.
No. 11 Oklahoma State (minus 16 1/2) at Colorado
Buffaloes have won 11 of last 13 against Cowboys ... OKLAHOMA STATE 34-24.
No. 12 Missouri (minus 26 1/2) at Iowa State
Tigers can clinch Big 12 North with win, Kansas loss ... MISSOURI 44-17.
No. 13 Georgia (minus 8) at Auburn
Tigers need one more win to be bowl eligible ... GEORGIA 28-14.
No. 16 BYU (minus 4) at Air Force
Cougars have won three straight against Falcons ... AIR FORCE 28-24.
No. 17 North Carolina (minus 2 1/2) at Maryland
Tar Heels victory would help sort out muddled ACC races ... MARYLAND 27-21.
Troy (plus 19 1/2) at No. 19 LSU
Postponed by Hurricane Ike in September ... LSU 35-20.
Boston College (plus 7) at No. 20 Florida State
Home team has lost three straight in series ... FLORIDA STATE 28-17.
California (plus 3) at No. 23 Oregon State
Beavers' Jacquizz Rodgers set Pac-10 freshman rushing record ... OREGON ST 30-24.
No. 25 Tulsa (minus 5) at Houston
Cougars could tie Tulsa for first in C-USA West ... HOUSTON 48-42.
---
Last week: 15-5 (straight); 11-9 (vs. points).
Season: 161-47 (straight); 101-92 (vs. points).

Recent NCAAF Discussions

Betting the 2017 NFL Draft on Tue, Apr 2017 by Blade
NFL Draft Preview on Tue, Apr 2017 by Blade
2017 Heisman Odds on Wed, Mar 2017 by Blade
College / NBA today on Sun, Mar 2017 by TtomBoBadly
SNOW on Tue, Mar 2017 by Michael Cash

NCAAF Headlines

NCAAF Top Stories

Thumbnail 2017 Heisman Trophy Odds There are plenty of candidates for the 2017 Heisman Trophy. Here is a look at the favorites entering the summer.
Thumbnail UCLA vs. Texas A&M Odds Texas A&M and UCLA will have one of the featured meetings during the opening weekend of college football....
Thumbnail Michigan vs. Florida Week 1 Odds One of the featured games in Week 1 of the College Football Season has two historic programs colliding when Michigan faces...

NCAAF Team Pages