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 ANN ARBOR, Mich. (AP) -Michigan's Mike Hart was injured in the first half against Purdue on Saturday, and was not in uniform after halftime.
The senior running back appeared to hurt his right ankle when he was tackled by Anthony Haygood.
Hart ran for 102 yards and two touchdowns in the first half - helping the Wolverines build a 24-point lead - and set a school rushing record with his seventh straight 100-yard game.
Brandon Minor, Hart's backup, limped off the field during the first drive of the second half after he appeared to hurt his left ankle. Minor was later carted off the field, and replaced by Carlos Brown.
Hart became Michigan's career rushing leader last week and entered Saturday's game leading the nation with 976 yards this season and 4,655 in his career.
Against the Boilermakers, Hart moved past Wisconsin's Anthony Davis for fifth among the Big Ten's career rushing leaders. He trails Wisconsin's Ron Dayne - who ran for a conference-record 7,125 yards - Ohio State's Archie Griffin, Indiana's Anthony Thompson and Michigan State's Lorenzo White.
Hart finished fifth in Heisman Trophy voting last year.
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