James was hurt early in Miami's 26-3 loss Saturday at Florida and didn't return.
Miami coach Randy Shannon said Monday that James could miss up to four weeks, depending on how severe the sprain is, but he didn't set a definitive timetable for the junior's return.
With James out, Graig Cooper would become the clear go-to running back. The two are essentially both atop the Miami depth chart.
Backups Derron Thomas and Shawnbrey McNeal could also get considerably more carries.

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