CLEVELAND (AP) -Alex Rodriguez hit career home run No. 501 and rookie Phil Hughes dominated Cleveland for six innings as the New York Yankees began a challenging stretch of games with a 6-1 win over the Indians on Friday night.
Rodriguez, who became the youngest player to reach the 500-homer plateau last week, connected for his 37th homer in the second inning off Fausto Carmona (13-7).
The shot to straightaway center set the tone for the Yankees, who improved to 21-8 since July 12.
Hughes (2-1) allowed one run and four hits in six innings. It was his second start since spending three months on the disabled list with a hamstring injury.
Derek Jeter had three hits and Bobby Abreu drove in a pair of runs for the Yankees, who were managed by bench coach Don Mattingly while Joe Torre served a one-game suspension.
Josh Barfield homered for the Indians, who all wore uniform No. 14 in a tribute to late Hall of Famer Larry Doby, the first black player in the AL.
Athletics 16, Tigers 10
DETROIT (AP) - Jack Cust hit a grand slam and drove in seven runs, and Oakland rallied after blowing a seven-run lead to beat reeling Detroit.
Travis Buck had four hits, scored three times and drove in three runs for Oakland. Donnie Murphy homered and drove in three runs as the A's handed Detroit its seventh loss in nine games.
Macay McBride (0-1) retired the first hitter of the sixth, but hit Buck before walking the next two batters. Cust then hit a 429-foot line drive to center field to give Oakland a 12-9 lead.
Ruddy Lugo (3-0) got the win pitching two innings of relief.
Neither starter was involved in the decision. Oakland's Joe Blanton gave up nine runs in four-plus innings, while Jordan Tata gave up seven runs in two-plus innings.
Orioles 6, Red Sox 5
BALTIMORE (AP) - Brian Roberts led off the ninth inning with a double and scored the game-winning run on a sacrifice fly by Nick Markakis, giving Baltimore a comeback win over Boston.
The Orioles rallied from a 5-1 deficit with a four-run eighth against Eric Gagne, then won it in the ninth against Hideki Okajima (3-1).
It was the first major league loss for Okajima. Baltimore rookie Jim Hoey (1-0) got four outs to earn his first big league win.
Baltimore's Erik Bedard and Boston rookie Daisuke Matsuzaka locked up in pitching duel until the eighth inning, when Boston sent 10 batters to the plate, six of whom got hits.
Matsuzaka allowed one run and four hits in seven innings. He struck out seven and now has 159, breaking the single-season record for Boston rookies set by Ken Brett (155 in 1970).

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