CLEVELAND (AP) -Jon Lester, whose rookie season ended suddenly when he was diagnosed with cancer, pitched six innings to win his first game in 11 months, leading Boston to a 6-2 victory over Cleveland on Monday night.
Lester allowed two runs and five hits to easily handle the Indians, the AL's best team at home. The 23-year-old left-hander was diagnosed with anaplastic large cell lymphoma, a highly treatable form of cancer, just days after he improved to 7-2 with a win over the Los Angeles Angels on Aug. 23. He underwent six chemotherapy sessions that eventually eradicated the disease.
Coco Crisp went 4-for-5 and scored three runs for Boston, which jumped to a 5-0 lead in the second off Jake Westbrook (1-6).
Manny Ramirez had two RBIs as the Red Sox (60-39) became the majors' first team to reach 60 wins.
Grady Sizemore hit a two-run homer for the Indians.
Blue Jays 6, Twins 4
TORONTO (AP) - Frank Thomas homered twice to raise his total to 503 and pull within one of Eddie Murray for 20th place as Toronto sent Johan Santana to a rare second-half loss.
Reed Johnson and Alex Rios hit solo shots off Santana (11-8), who allowed four homer in a game for the first time in 163 major league starts. He gave up three homers five times previously. Santana dropped to 41-6 following the All-Star game since the 2003 break. He allowed six runs and seven hits in five innings.
Thomas hit a two-run homer in the second that put the Blue Jays ahead 3-0 and another two-run drive in the fifth that made it 6-3. It was his 30th multihomer game, his first this year.
Justin Morneau hit two home runs for Minnesota, his fifth multihomer game this season, and Torii Hunter also homered.
Shaun Marcum (6-4) allowed four runs and eight hits in six innings.
Yankees 9, Royals 2
KANSAS CITY, Mo. (AP) - Roger Clemens got his 351st career victory and Alex Rodriguez became the first player to reach 100 RBIs this season as New York extended its winning streak to four.
Hideki Matsui, Johnny Damon and Jorge Posada drove in two runs each for the Yankees, who have won nine of 11. New York (52-46) moved six games over .500 for the first time this season.
Clemens (3-4) gave up two runs and four hits in seven innings, walking none and striking out three to raise his total to 4,641, second to Nolan Ryan on the career list. He improved to 6-0 against Kansas City in seven starts with the Yankees, and 25-12 versus the Royals overall.
Rodriguez was 1-for-3 with two walks and an RBI single off Ryan Braun in a five-run ninth.
Kansas City's Odalis Perez (5-9) gave up four run, eight hits and three walks in seven innings.
After reaching 20 hits in consecutive games for the first time in a century against Tampa Bay over the weekend, the Yankees had 13.
Tigers 9, White Sox 6
CHICAGO (AP) - Mike Hessman, called up from Triple-A Toledo earlier Monday, hit a go-ahead two-run single with two outs in the seventh for Detroit.
Curtis Granderson went 3-for-3, including a leadoff homer, walked, was hit by a pitch and drove in four runs for the Tigers.
Jason Grilli (4-2) pitched 1 1-3 innings of relief to earn the victory for the Tigers, who have won 12 of 16. Todd Jones pitched a perfect ninth for his 27th save.
Josh Fields hit a two-run homer for Chicago, which has lost eight of 11.
Trailing 6-5 in the seventh inning with one out, the Tigers rallied against Mark Buehrle (7-6). He gave up three consecutive singles to load the bases. Ehren Wassermann came in and got one out, but Hessman followed by dropping a single into right field.
Buehrle lasted 6 1-3 innings, but gave up a season-high seven runs and tied a career high with 14 hits allowed.
Rangers 8, Mariners 7
ARLINGTON, Texas (AP) - Sammy Sosa hit career home run No. 603 and had five RBIs for Texas.
Sosa's three-run homer in the fifth broke a 3-3 tie and was his 15th this season - one more than he had in 102 games for Baltimore in 2005 before sitting out last year.
Brad Wilkerson hit his 15th homer in the fifth, a two-run shot that chased Horacio Ramirez (5-3).
Sosa was 6-for-43 (.140) with one RBI over his last 12 games. He was in an 0-for-10 slump before his two-run double in the third put the Rangers ahead 3-2.
The Rangers brought in Eric Gagne in the ninth in a non-save situation and he gave up a three-run homer to Richie Sexson.
Jose Vidro was 4-for-4 with a walk and two RBIs for the Mariners, who lost their third straight.
Kevin Millwood (7-8) won despite allowing 12 runners on eight singles and four walks in 5 1-3 innings.
Athletics 12, Angels 6
ANAHEIM, Calif. (AP) - Mike Piazza hit a three-run homer and an RBI double and Mark Ellis added two solo homers and an RBI double for Oakland, which won for the third time in 14 games.
It was the second home run of the year and first since April 5 for Piazza, who returned from the 15-day disabled list on Friday.
The A's rocked Bartolo Colon for four runs in the first inning, then scored at least one run in each of the next five innings to take a 12-5 lead.
Colon (6-6) left after the first inning because of soreness in his right elbow. He threw 33 pitches, giving up four hits and a walk. It was the fourth time in his career he pitched one inning or less.
Joe Kennedy (2-9) allowed one hit in two scoreless innings to earn his first victory in 10 career decisions against the Angels.
End Capsules

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