The biggest game on the college football schedule Thursday pits Clemson at No. 21 Wake Forest. Let's check out the odds, trends, over/under totals and hand out a prediction.

Bet Clemson at No.21 Wake Forest

Kickoff: 7:30 PM ET

Odds: Oddsmakers from online sports book SBG Global have established Wake Forest 1.5-point favorite.

Over/Under: 42

Public Betting:

Current public betting information shows that 51% of bettors favor Wake Forest –1.5 over Clemson.

Top Betting Trends:

All games in this series since 1992

WAKE FOREST is 10-6 against the spread versus CLEMSON since 1992

CLEMSON is 11-5 straight up against WAKE FOREST since 1992

6 of 7 games in this series have gone OVER THE TOTAL since 1992

Games over the last 3 seasons

WAKE FOREST is 1-1 against the spread versus CLEMSON over the last 3 seasons 

CLEMSON is 2-0 straight up against WAKE FOREST over the last 3 seasons 

1 of 2 games in this series have gone OVER THE TOTAL over the last 3 seasons

All games played at WAKE FOREST since 1992

WAKE FOREST is 5-3 against the spread versus CLEMSON since 1992

CLEMSON is 5-3 straight up against WAKE FOREST since 1992

3 of 4 games in this series have gone OVER THE TOTAL since 1992

Games played at WAKE FOREST over the last 3 seasons.

WAKE FOREST is 1-0 against the spread versus CLEMSON over the last 3 seasons 

CLEMSON is 1-0 straight up against WAKE FOREST over the last 3 seasons 

1 of 1 games in this series have gone UNDER THE TOTAL over the last 3 seasons

Key Player Injuries

CLEMSON

[DL] Antwon Murchison downgraded to doubtful - Undisclosed - 09/27/08

[WR] Terrence Ashe missed last game, %27?%27. - Ankle - 09/21/08

[OL] Barry Humphries is expected to miss 4-6 weeks. - Knee - 09/04/08

[OL] Jamarcus Grant upgraded to probable. - Shoulder - 09/26/08

[OL] David Smith is expected to miss up to 3 weeks. - Ankle - 09/23/08

[OT] Chris Hairston missed last game, available only as an emergency. - Kn

[OT] Rashaad Jackson is out indefinitely. - Quad - 09/05/08

[DT] Jamie Cumbie likely to miss rest of season - Wrist - 09/04/08

WAKE FOREST

[OL] Ryan Britt is out indefinitely. - Knee - 08/19/08

Prediction:
This matchup is even across the board, so we’ll go with the team that has had the most success over the years in this series and that’s Clemson. They’ve won 11 of the past 16 meetings between these two teams and we like that considering they’re getting points. Wake might have the home field advantage and is coming off a bye, but the Deacons loss to Navy two weeks ago might have exposed some weaknesses. We predict Clemson over Wake 23-20.

Bet Clemson at No.21 Wake Forest

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