SAN FRANCISCO, CA (The Spread) – The White Sox have dominated the Giants in recent history and also have their ace on the mound tonight when they visit San Francisco for interleague play.

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According to oddsmakers from online sports book BetDSI, the White Sox are -113 money line road favorites versus the host Giants, who are +104 home dogs. The total for this 10:15PM ET start time is currently sitting at 6 runs.

The White Sox will throw ace Chris Sale, who is 10-2 with a 2.14 ERA and is 3-0 with a 2.52 ERA in 14 career interleague games including six starts. The Giants, meanwhile, will throw Ryan Vogelsong, who is 7-8 with a 3.77 ERA. He’ll face Chicago for the first time in his career but he’s 5-6 with a 3.91 ERA in interleague play.

The White Sox are 5-0 in their last five games versus the Giants and 4-0 in their last four games versus NL West opponents. They’re also 4-0 in their last four interleague games, 5-1 in their last six games following an off day and 6-1 in their last seven during Game 1 of a series.

On the other side, the Giants have been brutal, going 7-21 in their last 28 home games, 3-8 in their last 11 games following a loss and 7-20 in their last 27 games as an underdog. They’re also 0-5 in their last five games versus AL Central, were just swept by the Royals and are 1-10 in their last 11 home games with the total set at 6.5 runs or lower.

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